Objective: To characterize signalment, clinical and laboratory findings, treatment, and outcome in horses with rattlesnake envenomation in northern California.
Design: Retrospective case series.
Animals: 58 client-owned horses evaluated for rattlesnake envenomation at 2 referral hospitals from 1992 to 2009.
Procedures: Records of horses with rattlesnake envenomation were reviewed, and data concerning signalment, clinical and laboratory findings, treatment, and outcome were collected. In addition, a rattlesnake-bite severity score (RBSS) was assigned to each horse. Variables were compared between horses that survived and those that did not.
Results: The overall mortality rate was 9%. Nine horses received antivenin; no complications were reported and none of the 9 died. The most common laboratory findings associated with severity of envenomation were thrombocytopenia, hypoproteinemia, hyperlactatemia, and a high RBSS.
Conclusions And Clinical Relevance: Most horses in this study had a good prognosis after being bitten by rattlesnakes. Laboratory and clinical examination findings may be useful for identifying horses with a poorer prognosis. Treatment with antivenin may be beneficial and warrants further evaluation.
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http://dx.doi.org/10.2460/javma.238.5.631 | DOI Listing |
Pharmaceuticals (Basel)
January 2025
Laboratory of Toxinology and Cardiovascular Research, University of Western São Paulo (UNOESTE), Presidente Prudente 19050-680, SP, Brazil.
We compared the enzymatic, coagulant, and neuromuscular activities of two variants (yellow-CDRy and white-CDRw) of venom with a sample of (CDT) venom and examined their neutralization by antivenom against CDT venom. The venoms were screened for enzymatic and coagulant activities using standard assays, and electrophoretic profiles were compared by SDS-PAGE. Neutralization was assessed by preincubating venoms with crotalic antivenom and assaying the residual activity.
View Article and Find Full Text PDFToxicon
January 2025
Laboratório de Fisiopatologia, Instituto Butantan, São Paulo, Brazil; Laboratório de Herpetologia, Instituto Butantan, São Paulo, Brazil; Interunidades em Biotecnologia, Universidade de São Paulo - Instituto de Pesquisas Tecnológicas - Instituto Butantan, São Paulo, Brazil. Electronic address:
Fibrinogen is a common target of SVMP and SVSP. These toxins can destructively cleave fibrinogen, leading to the depletion of its levels. Herein we comparatively describe the fibrinogenolytic activity of the venom of Bothrops and Crotalus snakes, viperids of high epidemiological importance in Brazil.
View Article and Find Full Text PDFTrans R Soc Trop Med Hyg
January 2025
University of Florida College of Medicine, Gainesville, 32610 USA.
Background: Venomous snakes are among the most lethal animals worldwide and envenomation survivors face lifelong morbidities. Envenomation is colloquially considered highly prevalent in the US state of Florida, yet envenomation trends here are currently unassessed.
Methods: We present a comprehensive analysis of causes, characteristics and treatments of Florida's snake envenomations via medical records review of envenomated patients presenting to a major academic medical centre between 2002 and 2022.
Toxins (Basel)
December 2024
Poison Control Center, The University of Arizona College of Pharmacy, Tucson, AZ 85724, USA.
The onset, progression, and severity of pain following rattlesnake envenomation are highly variable between patients. Pain can be severe and persistent, seemingly refractory to opioid analgesics. The ability of antivenom to directly relieve pain has not been well studied.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
Snakebite envenoming is a significant health threat, particularly in tropical regions, causing substantial morbidity and mortality. Traditional treatments, including antivenom therapy, have limitations and associated risks. This research aims to discover novel phytochemical antidotes for snakebites, specifically targeting the western diamondback rattlesnake () venom metalloproteinase Atrolysin.
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