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Summary: An oral contraceptive pill (OCP)-induced increase in total cortisol lead to reversible suppression of the hypothalamic-pituitary-adrenal (HPA) axis and insulin resistance (IR) in a patient with Addison's disease. We suggest that this might influence the choice of an OCP in such patients. A 20-year-old female was diagnosed with Addison's disease (cortisol: 44 nmol/L, adrenocorticotropic hormone (ACTH): >500 pg/mL) and started on hydrocortisone (HC).
View Article and Find Full Text PDFToripalimab combined with bevacizumab plus chemotherapy as first-line treatment for refractory recurrent or metastatic cervical cancer: a single-arm, open-label, phase II study (JS001-ISS-CO214).
J Gynecol Oncol
October 2024
National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China.
Article Synopsis
- - The study aimed to assess the effectiveness and safety of combining toripalimab, bevacizumab, and platinum-based chemotherapy as a primary treatment for recurrent or metastatic cervical cancer (CC).
- - In a trial involving 24 patients, the combination therapy resulted in an objective response rate of 83.3% and a disease control rate of 95.8%, with a median progression-free survival of 22.6 months.
- - Common side effects included neutropenia and thyroid dysfunction, but there were no severe immune-related adverse events, indicating that this treatment strategy could be a viable option for addressing R/M CC.
Application value of opioid-free anesthesia in renal cyst decompression by laparoscopy.
Cir Cir
October 2024
Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Objective: The objective of the study was to analyze the application value of opioid-free anesthesia (OFA) in renal cyst decompression by laparoscopy.
Method: A total of 124 patients undergoing renal cyst decompression by laparoscopy in our hospital were selected and divided into opioid anesthesia (OA) and OFA groups (n = 62). Fentanyl and remifentanil were used for anesthesia induction in the OA group, while lidocaine and dexmedetomidine were employed for anesthesia induction in the OFA group.
ACTH stimulation and oral salt loading tests detect biochemical outcome early after primary aldosteronism surgery.
J Clin Endocrinol Metab
October 2024
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama, Japan.
Background: In primary aldosteronism (PA), the biochemical outcomes of the Primary Aldosteronism Surgical Outcome study are used to assess aldosterone hypersecretion 6-12 months after surgery. However, few studies have investigated whether the outcomes can be predicted in the early postoperative period. In this retrospective study, we evaluated whether the adrenocorticotropin stimulation test (AST) and oral salt loading test (OST) performed immediately after surgery could predict biochemical outcomes 1 year after surgery.
View Article and Find Full Text PDFCase Report: Adrenal schwannoma associated with ganglioneuroma.
Front Surg
September 2024
Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.
Article Synopsis
- An adrenal collision tumor (ACT) consists of distinct tumors, like adrenal schwannoma and ganglioneuroma, that coexist in adrenal tissue without overlapping; these cases are rare and hard to diagnose due to unusual clinical signs and imaging results.
- A 37-year-old man was diagnosed with a left adrenal mass, initially thought to be a pheochromocytoma, but post-surgery, it was found to be a combination of adrenal schwannoma and ganglioneuroma.
- This case underscores the complexity of adrenal tumors, highlighting the importance of postoperative analysis for accurate diagnosis and treatment despite the challenges in identifying the type of adrenal mass before surgery.*
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