We describe the present status of an ongoing project to develop a Tandem-ElectroStatic-Quadrupole (TESQ) accelerator facility for Accelerator-Based (AB)-BNCT. The project final goal is a machine capable of delivering 30 mA of 2.4 MeV protons to be used in conjunction with a neutron production target based on the (7)Li(p,n)(7)Be reaction. The machine currently being constructed is a folded TESQ with a high-voltage terminal at 0.6 MV. We report here on the progress achieved in a number of different areas.
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http://dx.doi.org/10.1016/j.apradiso.2011.01.040 | DOI Listing |
Phys Med Biol
January 2025
Centre National de la Recherche Scientifique, LPSC, 53 avenue des Martyrs, Grenoble, 38026, FRANCE.
This study aims to determine the optimal structure of the Beam Shaping Assembly (BSA) for an AB-BNCT (Accelerator-Based Boron Neutron Capture Therapy) facility. The aim is to maximize the possible depth of treatment for glioblastoma while ensuring that a treatment time constraint is not exceeded. Approach.
View Article and Find Full Text PDFJ Radiat Res
January 2025
Particle Radiation Oncology Research Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2, Asashiro-Nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
The accelerator-based boron neutron capture therapy (BNCT) system has been approved for specific cases covered by health insurance, and clinical trials for new cases in Japan are currently being conducted on other systems. Owing to the progress of accelerator-based BNCT, the operation of medical physics must be rendered more efficient. A water phantom is used for the quality assurance (QA) of the BNCT beam output procedure; however, a solid phantom is preferred for routine QA because of its ease of use.
View Article and Find Full Text PDFSci Rep
September 2024
Department of Atomic, Molecular and Nuclear Physics, Universidad de Granada, 18072, Granada, Spain.
Boron Neutron Capture Therapy (BNCT) is performed using high-intensity neutron sources; however, the energy of the primary neutrons is too high for direct patient irradiation. Thus, neutron moderation is mandatory and is performed using a device known as a Beam Shaping Assembly (BSA). Due to the differences in flux and energy spectra between neutron sources, each facility needs a dedicated BSA design, whether it is based on a nuclear reactor or, more recently, on an accelerator.
View Article and Find Full Text PDFAppl Radiat Isot
December 2024
Sino-French Institute of Nuclear Engineering and Technology, Sun Yat-sen University, Zhuhai, Guangdong, 519082, China; United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Ltd, Guangzhou, China. Electronic address:
Boron Neutron Capture Therapy is being promoted with the development of accelerator neutron sources, and many new accelerator-based BNCT facilities are being built. In Particle Accelerator Facility project of Sun Yat-sen University, we plan to build a terminal for BNCT research based on an 8 MeV, CW 3 mA proton accelerator. In this paper, we present a beam-shaping assembly for this proton accelerator with such low 24 kW beam power, using composite moderator materials composed of five elements: Mg, Al, F, O, and Li.
View Article and Find Full Text PDFJ Water Health
August 2024
iThemba Laboratory for Accelerator Based Sciences, Faure, South Africa.
The neutron activation of stable isotopes in environmental matrices, such as soil and groundwater, is a critical aspect of assessing the impact of radionuclide production facilities on the surrounding ecosystem. The envisioned Low-Energy Radioactive Ion Beams (LERIB) facility at the iThemba LABS, South Africa is anticipated to generate significant sources of ionising radiation. The study investigated the possible repercussions of neutron irradiation stemming from the facility, focusing on the activation of stable isotopic compositions in the environment.
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