Background: Aortic arch replacement remains among the most technically challenging cardiovascular operations, incurring considerable risk for perioperative death and stroke. The trifurcated graft technique, in which a double Y-graft is used to connect brachiocephalic branches to the main aortic graft, was recently developed to simplify arch reconstruction, reduce embolization, and minimize related cerebral ischemia. We examined early outcomes of aortic arch replacement performed by using single or double Y-graft variations of this technique.
Methods: Between December 2006 and May 2009, the Y-graft technique was used to perform aortic arch replacement in 55 patients. Thirty-three patients had prior median sternotomy (60%), and 34 (62%) had ascending aortic dissection. Axillary cannulation was used in 52 patients (95%), and hypothermic circulatory arrest and antegrade cerebral perfusion were used in all patients. Median systemic and cerebral circulatory arrest times were 65 minutes and 0 minutes, respectively. A first-stage elephant trunk repair was performed in 46 patients (84%). Follow-up data were obtained for all patients.
Results: There were no in-hospital deaths and one 30-day death (2%). Three patients (5%) had strokes, 1 of which was transient. Actuarial 1-year and 2-year survival rates were 80.0% ± 5.4% and 77.6% ± 5.7%, respectively. Thirty-one of the elephant trunk patients (67%) subsequently underwent second-stage completion procedures, 5 (16%) of them endovascular.
Conclusions: Early results of aortic arch replacement by the Y-graft technique compare favorably with those of traditional approaches. The technique enables effective delivery of antegrade cerebral perfusion during complex arch procedures and incurs only a low risk of neurologic sequelae.
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http://dx.doi.org/10.1016/j.athoracsur.2010.11.008 | DOI Listing |
Perfusion
January 2025
Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Objective: Elderly patients are less likely to undergo surgery for an acute type A aortic dissection (ATAAD). This study aims to understand the risks of surgical treatment in patients 75 and older.
Methods: This was a retrospective study using an institutional database of patients who underwent ATAAD repair from 2007 to 2021.
J Med Genet
January 2025
Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.
Background: Individuals harbouring pathogenic variants are at risk for aneurysms/dissections throughout the arterial tree. Based on prior reports of sex differences in thoracic aortic aneurysm/dissection, we investigated the sexual dimorphism for vascular events in variant-harbouring patients.
Methods: We analysed two large pedigrees comprising 84 individuals segregating pathogenic missense variants affecting the same p.
A A Pract
January 2025
Department of Anesthesiology, University of Kansas Medical Center, Kansas City, Kansas.
Transcatheter aortic valve replacement (TAVR) is a common treatment for severe aortic stenosis (AS), but it carries the risk of severe complications, including device embolization. We present a case of a TAVR valve embolization into the left ventricular outflow tract (LVOT), diagnosed with transesophageal echocardiography (TEE) shortly after device deployment. The dislodged valve was successfully retrieved from the LVOT into the aorta, flattened, and stabilized with a thoracic endovascular aneurysm repair (TEVAR) stent, enabling the successful implantation of a new TAVR valve.
View Article and Find Full Text PDFArterioscler Thromb Vasc Biol
January 2025
Division of Cardiology, Department of Medicine, University of Washington (S.S., S.J., N.S., C.Y.L., L.L., D.A.D.).
Front Pharmacol
December 2024
Department of Clinical Pharmacy, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Background: Recombinant human granulocyte-colony stimulating factors (G-CSF)-induced aortitis is a rare but particularly serious adverse event, commonly seen in cancer patients undergoing chemotherapy. The aim of this article is to clarify the clinical characteristics of G-CSF- induced aortitis and provide effective references for clinical diagnosis and intervention.
Methods: Case reports of adverse reactions of aortitis induced by G-CSF were collected from the relevant databases.
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