AI Article Synopsis
- The hippocampus is crucial for learning and memory, with calcitonin gene-related peptide (CGRP) and its receptors present in this area.
- CGRP was found to inhibit long term potentiation (LTP), a process important for strengthening synapses, in the CA1 region of rat hippocampal neurons when stimulated with high frequency.
- The negative effects of CGRP on LTP can be blocked by a specific receptor antagonist, suggesting that CGRP and its receptor play a significant role in modulating synaptic plasticity in the hippocampus.
Article Abstract
It is well known that hippocampus plays important roles in learning and memory. Both calcitonin gene-related peptide (CGRP) and CGRP receptors are found in hippocampus. In the present study we explored the influence of CGRP on long term potentiation (LTP) in hippocampal Schaffer collateral-CA1. Our results demonstrated that CGRP inhibited the LTP induced by high frequency stimulation (HFS) in hippocampal CA1 neurons in rat brain slices. The inhibitory effect was blocked by CGRP receptor-1 antagonist CGRP 8-37. The results indicate that both CGRP and CGRP receptor 1 are involved in the modulation process of LTP in hippocampus of rats.
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| http://dx.doi.org/10.1016/j.neulet.2011.02.036 | DOI Listing |
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