Aims: To determine the incidence of concurrent substance misuse among individuals entering first-episode psychosis treatment, and examine whether patients with concurrent substance misuse differ on variables relevant to service planning.
Methods: Consecutive patients (n=376) were assessed using standardized instruments.
Results: Twenty-two per cent met abuse or dependence criteria for a single substance, and 8% met criteria for two substances. Most met criteria for marijuana or marijuana and alcohol. The majority of patients with a concurrent disorder were male, and on average they were 3.5 years younger at psychosis onset. Patients with a concurrent disorder experienced worse 'positive' and anxiety symptoms in the month before treatment. Premorbidly they had better social functioning, but worse academic functioning.
Conclusions: There are important differences between patients entering first-episode psychosis treatment with and without a concurrent substance misuse. Early intervention efforts might be informed by our accumulating knowledge about the characteristics of patients who have both disorders.
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http://dx.doi.org/10.1111/j.1751-7893.2008.00100.x | DOI Listing |
Exp Clin Psychopharmacol
January 2025
Substance Use and Concurrent Disorders Program, Royal Ottawa Mental Health Centre.
The role of craving in opioid use disorder (OUD) has been well established with respect to heroin but less so with prescription opioids. This pilot study, conducted in 18 treatment-seeking patients with prescription OUD and 18 healthy volunteers, assessed spontaneous (in the moment) and cue-induced craving and their relationship to depression and anxiety. Patients (vs.
View Article and Find Full Text PDFJ Hazard Mater
December 2024
SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China; Anti-Drug Technology Center of Guangdong Province and National Anti-Drug Laboratory Guangdong Regional Center, Guangdong Provincial Key Laboratory of Psychoactive Substances Monitoring and Safety, Guangzhou 510230, China. Electronic address:
Dextromethorphan (DXM) is a common ingredient in cough and cold remedies. Despite its widespread presence in aquatic environments, the impact of DXM on fish remains largely unknown. This study evaluated the developmental impairment of zebrafish embryos exposed to DXM from 2 hours post-fertilization (hpf) to 14 days post-fertilization (dpf) at five different exposure concentrations: 0.
View Article and Find Full Text PDFJ ECT
December 2024
From the Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Objectives: We studied the acceptability, feasibility, tolerability, and preliminary effectiveness of combined cue exposure and anodal high-definition transcranial direct current stimulation (HD-tDCS) on the right dorsolateral prefrontal cortex (DLPFC) on cannabis craving in cannabis use disorder (CUD).
Methods: We randomly assigned 48 participants equally in 4 groups: A, tDCS and cannabis cue exposure; B, tDCS and neutral image; C, sham tDCS and cue exposure; and D, sham tDCS and neutral image. The images were validated by Delphi consensus.
Front Psychiatry
December 2024
Department of Health and Nursing Sciences, Inland Norway University of Applied Sciences, Elverum, Norway.
Youth Flexible Assertive Community Treatment (Youth Flexible ACT) is a service model for children and young people with severe mental health problems and complex needs aimed at providing integrated, continuous and holistic care. Studies on young people's experiences of Youth Flexible ACT or similar models are scarce. The present qualitative study aimed to explore and describe how young people with severe mental health problems and complex needs experience follow-up and treatment provided by Youth Flexible ACT teams.
View Article and Find Full Text PDFNicotine Tob Res
December 2024
Professor, Dept of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, India.
Introduction: The dearth of population-based data on polysubstance use, especially in young emerging adults, presents a critical gap in understanding public health challenges, particularly in rural India, where tobacco and oral cancer are prevalent. This study addresses this gap by investigating the prevalence and patterns of substance use, with a focus on young emerging adults (18-29 years) within a high-risk cohort for oral cancer in Varanasi, India.
Methods: The study involved a cross-sectional analysis of baseline data from 10,101 participants within a high-risk cohort in rural settings of the Varanasi district between December 2020-June 2023.
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