The programmed degradation of the RAG-2 enzyme upon entry to S phase restricts V(D)J recombination to the G0-G1 phase of the cell cycle. In this issue of Immunity, Zhang et al. (2011) show that this is critical to prevent lymphoma formation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059897 | PMC |
| http://dx.doi.org/10.1016/j.immuni.2011.02.007 | DOI Listing |
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RAG-2 unleashed: lymphocytes beware.
Immunity
February 2011
Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA.
The programmed degradation of the RAG-2 enzyme upon entry to S phase restricts V(D)J recombination to the G0-G1 phase of the cell cycle. In this issue of Immunity, Zhang et al. (2011) show that this is critical to prevent lymphoma formation.
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