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Targeted and non-targeted metabolic analysis of chlorpromazine in grass carp as well as the in-silico and metabolomics toxicity assessment.
J Hazard Mater
January 2025
Jiangsu Institute for Food and Drug Control, 6 Beijing West Road, Nanjing 210008, China. Electronic address:
Chlorpromazine (CPZ) is an abused sedative that is extensively metabolized in organisms. However, the metabolic pathway of CPZ in aquatic organisms is still unclear. In this study, CPZ metabolites was analyzed in grass carp exposed to CPZ in the raising water using ultrahigh-performance liquid chromatography coupled with quadrupole Orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS).
View Article and Find Full Text PDFIdentification and Characterization of a Protease Producing Strain From Tannery Waste for Efficient Dehairing of Goat Skin.
Biomed Res Int
January 2025
Center for Personalized Nanomedicine, Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia.
Environmental pollution has been a significant concern for the last few years. The leather industry significantly contributes to the economy but is one of Bangladesh's most prominent polluting industries. It is also responsible for several severe diseases such as cancer, lung diseases, and heart diseases of leather workers because they use bleaching agents and chemicals, and these have numerous adverse effects on human health.
View Article and Find Full Text PDFMicrosatellite/SSR dataset: characterization of apple cultivars of the German Fruit Genebank.
Sci Data
January 2025
Julius Kühn Institute (JKI), Federal Research Centre for Cultivated Plants, Institute for Breeding Research on Fruit Crops, Pillnitzer Platz 3a, 01326, Dresden-Pillnitz, Germany.
The German Fruit Genebank is a decentralized network focused on coordinating various germplasm collections across Germany to conserve and utilize the genetic resources of native fruit species. This aim emphasizes the necessity of trueness-to-type validation of genetic resources based on pomological and molecular characteristics. Between 2009 and 2021, multiple projects were undertaken to create an inventory of the apple (Malus ssp.
View Article and Find Full Text PDFIn Silico Subtractive Proteome Analysis to Design Multi-Epitope-Based Subunit Vaccine against .
J Microbiol Biotechnol
November 2024
Fatemah AlMalki, Biology Department, College of Science and Humanities- Al Quwaiiyah, Shaqra University, Al Quwaiiyah 19257, Saudi Arabia.
is a gram-negative, facultatively anaerobic bacterium typically found in the oropharynx and respiratory tract of humans. It is responsible for various infections, including head-and-neck infections, pericarditis, and abscesses of the deltoid, perirenal tissue, brain, and liver. Increasing antibiotic resistance requires urgent identification of novel drug targets to fight this bacterium.
View Article and Find Full Text PDFQualitative confirmation of 30 phencyclidine analogs in human blood and urine using GC-HRMS and a self-built library search.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Department of Forensic Toxicology, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Academy of Forensic Science, Shanghai 200063 China. Electronic address:
Introduction: Phencyclidine, a dissociative anesthetic with hallucinogenic effects, is commonly abused as a recreational drug. Phencyclidine analogs are compounds produced by substitutions of the phenyl and piperidine rings of phencyclidine. Illegal use of phencyclidine and its analogs has symptoms such as addiction, confusion, and increased tendencies toward violence.
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