AI Article Synopsis
- Neovascular Age Related Macular Degeneration (ARMD) is a serious condition with limited treatment options, and this study evaluated the effectiveness and safety of Ranibizumab in patients.
- A retrospective study included 126 eyes from 112 patients treated between 2006-2008, analyzing various factors affecting treatment results and side effects.
- Results indicated that Ranibizumab was effective for up to 18 months, especially in patients with better baseline visual acuity, and was generally safe with few adverse reactions.
Article Abstract
Background And Objectives: Neovascular Age Related Macular Degeneration (ARMD) is a chronic and degenerative disease. Current treatment options are limited and have shown to slow disease progression. The aim of this study was to assess Ranibizumab effectiveness and safety and to describe patients' demographic and clinical characteristics.
Patients And Method: We conducted a retrospective observational study including all patients who had started treatment between 1/12/2006 and 31/12/2008, and were followed up until 31/03/2009. A bivariate analysis on months 4, 12 and 18 and two logistic regression models were performed to analyze the influence of demographic and clinical factors on the effectiveness and durability of treatment. Adverse reactions were collected as described in the medical records to assess safety.
Results: A total of 126 eyes of 112 patients were recruited. The mean age was 77.7 (± 6.0) years. The mean durability of treatment was 18.2 months, and it was higher in the group of patients who started treatment with visual acuity (VA) > 0.1 (p<0.001). Ranibizumab therapy maintained AV over baseline at 18 months. None of the studied variables showed any influence on treatment effectiveness. However, baseline visual acuity influenced on treatment duration, being higher in the group of patients with AV > 0.1.
Conclusions: Ranibizumab was shown to be effective until 18 months. Early diagnosis of AMD could lead to an earlier treatment start, when patients present a higher AV, in order to optimize the benefits of treatment. Ranibizumab was well tolerated and safe in most patients.
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| http://dx.doi.org/10.1016/j.medcli.2010.06.033 | DOI Listing |
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