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Key Regulators of Parasite Biology Viewed Through a Post-Translational Modification Repertoire.
Proteomics
December 2024
Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving "One Health". Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and host-switching, which are controlled by various regulatory machineries including protein post-translational modifications (PTMs).
View Article and Find Full Text PDFSelf-propelled enzyme-controlled IR-mesoporous silica Janus nanomotor for smart delivery.
J Colloid Interface Sci
October 2024
Nanosensors and Nanomachines Group, Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address:
Here, we report the preparation of a novel Janus nanoparticle with opposite Ir and mesoporous silica nanoparticles through a partial surface masking with toposelective modification method. This nanomaterial was employed to construct an enzyme-powered nanomachine with self-propulsion properties for on-command delivery. The cargo-loaded nanoparticle was provided with a pH-sensitive gate and unit control at the mesoporous face by first attaching boronic acid residues and further immobilization of glucose oxidase through reversible boronic acid esters with the carbohydrate residues of the glycoenzyme.
View Article and Find Full Text PDFSustainable protein regeneration in encapsulated materials.
Cell Syst
March 2024
INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany. Electronic address:
Zhu et al. introduce MELG (materials engineered by living grafting), combining engineered microbes with non-living scaffolds for functional protein regeneration within. These MELGs can be used for long-term controlled release, enzyme-mediated biocatalysis, and DNA purification.
View Article and Find Full Text PDFEnzyme-Mediated Exponential Glucose Release: A Model-Based Strategy for Continuous Defined Fed-Batch in Small-Scale Cultivations.
Bioengineering (Basel)
January 2024
Institute of Biotechnology, Chair of Bioprocess Engineering, Technische Universität Berlin, 13355 Berlin, Germany.
Article Synopsis
- Miniaturized cultivation systems can improve bioprocess development efficiency but lack the necessary miniaturized pumps for fed-batch mode.
- Enzyme-mediated glucose release from starch-derived polymers offers a continuous glucose supply, but its effectiveness is impacted by various factors like enzyme concentration and culture conditions.
- A new model-based approach has been developed to enable precise control over glucose release, allowing for consistent growth rates in mini-bioreactors, thus simplifying continuous feeding in small-scale systems.
Lanthanide-Based Probes for Imaging Detection of Enzyme Activities by NIR Luminescence, T1- and ParaCEST MRI.
Angew Chem Int Ed Engl
April 2024
Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans, rue Charles Sadron, 45071, Orléans, France.
Applying a single molecular probe to monitor enzymatic activities in multiple, complementary imaging modalities is highly desirable to ascertain detection and to avoid the complexity associated with the use of agents of different chemical entities. We demonstrate here the versatility of lanthanide (Ln) complexes with respect to their optical and magnetic properties and their potential for enzymatic detection in NIR luminescence, CEST and T1 MR imaging, controlled by the nature of the Ln ion, while using a unique chelator. Based on X-ray structural, photophysical, and solution NMR investigations of a family of Ln DO3A-pyridine model complexes, we could rationalize the luminescence (Eu, Yb), CEST (Yb) and relaxation (Gd) properties and their variations between carbamate and amine derivatives.
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