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In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens. | LitMetric
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In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.

Stephane Desgranges Florie Le Prieult Alan Daly Jennifer Lydon Marian Brennan Dilip K Rai Anusha P Subasinghage Chandralal M Hewage Sally-Ann Cryan Catherine Greene Noel G McElvaney Timothy P Smyth Deirdre Fitzgerald-Hughes Hilary Humphreys Marc Devocelle

Antimicrob Agents Chemother

Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2, Ireland.

Published: May 2011

The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088215PMC
http://dx.doi.org/10.1128/AAC.01384-10DOI Listing

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