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Prussian Blue Analogues "Dressed" in MXene Nanosheets Tightly for High Performance Lithium-Ion Batteries.
Adv Mater
January 2025
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002, P. R. China.
MXenes, have been considered as a new generation anode material in lithium-ion batteries for lower lithium-ion diffusion barriers and superior conductivity. Unfortunately, their structures are prone to aggregation and stacking, hindering further shuttle of lithium ions and electrons, resulting in lower discharge capacity. Therefore, the introduction of interlayer spacers for the preparation of MXene-based hybrids has attracted much attention.
View Article and Find Full Text PDFOpposed Aromatic Surfaces Behave as Independent Binding Sites for Carbohydrate Stacking: Analysis of Sandwich-like CH/π/CH Complexes.
JACS Au
November 2024
Instituto de Química Orgánica General (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
CH/π bonds are versatile elements for the construction of complex molecular architectures, thus playing key roles in many biomolecular recognition processes. Although seldom acknowledged, aromatic units are inherently bivalent and can participate in CH/π bonds through either face simultaneously, leading to the formation of stacking complexes. This sandwich-like arrangement is by far the most common in natural complexes and could potentially lead to negative cooperativity due to unfavorable polarization or electrostatic effects, especially when polarized CH fragments are involved.
View Article and Find Full Text PDFSynthetic macrolides overcoming MLSK-resistant pathogens.
Cell Discov
July 2024
Key Laboratory of Medicinal Molecule Science and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China.
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base A2058 or its G2058 mutation, while the presence of unmodified A2058 is crucial for high selectivity of traditional MLSK in targeting pathogens over human cells. The absence of effective modes of action reinforces the prevailing belief that constitutively antibiotic-resistant Staphylococcus aureus remains impervious to existing macrolides including telithromycin. Here, we report the design and synthesis of a novel series of macrolides, featuring the strategic fusion of ketolide and quinolone moieties.
View Article and Find Full Text PDFA Strong, Tough, and Stable Composite with Nacre-Inspired Sandwich Structure.
Adv Mater
July 2024
School of Chemistry, Beihang University (BUAA), Beijing, 100191, P. R. China.
Improving the fracture resistance of nacre-inspired composites is crucial in addressing the strength-toughness trade-off. However, most previously proposed strategies for enhancing fracture resistance in these composites have been limited to interfacial modification by polymer, which restricts mechanical enhancement. Here, a composite material consisting of graphene oxide (GO) lamellae and nanocrystalline reinforced amorphous alumina nanowires (NAANs) has been developed.
View Article and Find Full Text PDFMolecular Insights into the Specific Targeting of G-Quadruplex by Thiazole Peptides.
Int J Mol Sci
January 2024
Institute of Ageing Research, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou 311121, China.
Article Synopsis
- Stabilization of G-quadruplexes (G4s) in proto-oncogene promoters can inhibit gene expression and is a potential cancer treatment strategy, but existing G4 stabilizers lack selectivity.
- A unique crescent-shaped thiazole peptide shows a preference for stabilizing a specific G4, prompting investigation into its selective binding mechanisms through simulations and molecular docking.
- The study found that the thiazole peptide and its analogue create a favorable "sandwich-like" interaction with the G4 structure, leading to increased binding affinity, primarily due to van der Waals interactions, and these insights can aid in developing new selective G4 stabilizers.
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