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Levantilides A and B, 20-membered macrolides from a Micromonospora strain isolated from the Mediterranean deep sea sediment. | LitMetric
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Levantilides A and B, 20-membered macrolides from a Micromonospora strain isolated from the Mediterranean deep sea sediment.

Andrea Gärtner Birgit Ohlendorf Dirk Schulz Heidi Zinecker Jutta Wiese Johannes F Imhoff

Mar Drugs

Kieler Wirkstoff-Zentrum at IFM-GEOMAR (Leibniz Institute of Marine Sciences), AmKiel-Kanal 44, 24106 Kiel, Germany.

Published: January 2011

Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6 ‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039473PMC
http://dx.doi.org/10.3390/md9010098DOI Listing

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