We consider functional measurement error models, i.e. models where covariates are measured with error and yet no distributional assumptions are made about the mismeasured variable. We propose and study a score-type local test and an orthogonal series-based, omnibus goodness-of-fit test in this context, where no likelihood function is available or calculated-i.e. all the tests are proposed in the semiparametric model framework. We demonstrate that our tests have optimality properties and computational advantages that are similar to those of the classical score tests in the parametric model framework. The test procedures are applicable to several semiparametric extensions of measurement error models, including when the measurement error distribution is estimated non-parametrically as well as for generalized partially linear models. The performance of the local score-type and omnibus goodness-of-fit tests is demonstrated through simulation studies and analysis of a nutrition data set.
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http://dx.doi.org/10.1111/j.1467-9868.2010.00751.x | DOI Listing |
J Am Med Inform Assoc
January 2025
Information Systems and Business Administration, Johannes Gutenberg University, Mainz 55128, Germany.
Objectives: Explanations help to understand why anomaly detection algorithms identify data as anomalous. This study evaluates whether robustly standardized explanation scores correctly identify the implausible variables that make cancer data anomalous.
Materials And Methods: The dataset analyzed consists of 18 587 truncated real-world cancer registry records containing 8 categorical variables describing patients diagnosed with bladder and lung tumors.
Biometrics
January 2025
Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.
The ICH E9 addendum on estimands in clinical trials provides a framework for precisely defining the treatment effect that is to be estimated, but says little about estimation methods. Here, we report analyses of a clinical trial in type 2 diabetes, targeting the effects of randomized treatment, handling rescue treatment and discontinuation of randomized treatment using the so-called hypothetical strategy. We show how this can be estimated using mixed models for repeated measures, multiple imputation, inverse probability of treatment weighting, G-formula, and G-estimation.
View Article and Find Full Text PDFJ Opt Soc Am A Opt Image Sci Vis
August 2024
Frequency-domain near-infrared spectroscopy (FD-NIRS) is a noninvasive method for quantitatively measuring optical absorption and scattering in tissue. This study introduces structured interrogation (SI) as an interference-based approach for implementing FD-NIRS in order to enhance optical property estimation in multilayered tissues and sensitivity to deeper layers. We find that, in the presence of realistic noise, SI accurately estimates properties and chromophore concentrations with less than a 5% error.
View Article and Find Full Text PDFEnviron Sci Technol
January 2025
Department of Chemistry, University of California Berkeley, Berkeley, California 94720, United States.
Deployment of large numbers of low capital cost sensors to increase the spatial density of air quality measurements enables applications that build on mapping air at neighborhood scales. Effective deployment requires not only low capital costs for observations but also a simultaneous reduction in labor costs. The Berkeley Environmental Air Quality and CO Network (BEACON) is a sensor network measuring O, CO, NO, and NO, particulate matter (PM), and CO at dozens of locations in cities where it is deployed.
View Article and Find Full Text PDFDisabil Rehabil
January 2025
Department of Physiotherapy, University of Murcia, Murcia, Spain.
Purpose: To synthesize evidence regarding psychometric properties of the Mini-Balance Evaluation Systems Test (Mini-BESTest) in assessing postural control.
Method: Six databases were searched until October 15th, 2024. Two authors independently assessed the methodological quality and results of studies using the COSMIN checklist and Terweés criteria.
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