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Effectiveness and safety of denosumab on osteoporosis treatment in kidney transplant recipients.
Kidney Res Clin Pract
November 2024
Division of Nephrology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Republic of Korea.
Background: Denosumab has been reported to improve bone mineral density (BMD), but the clinical impact of denosumab on osteoporosis in kidney transplant recipients (KTRs) remains controversial.
Methods: We analyzed 98 KTRs who used denosumab from 2018 to 2023. We investigated the change in BMD, laboratory findings, complications of denosumab, fracture risk assessment tool (FRAX) score, acute rejection within 1 year, and graft failure.
Trabecular Bone Score in Individuals with Chronic Spinal Cord Injury: A Cross-Sectional Study.
Top Spinal Cord Inj Rehabil
December 2024
KITE - Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.
Objectives: To describe lumbar spine (LS) trabecular bone score (TBS) values after SCI, and to explore the differences in fractures risk assessment between FRAX® and TBS-adjusted FRAX® in individuals living with chronic SCI.
Methods: Baseline dual-energy x-ray absorptiometry (DXA) scans from an established cohort were acquired using a Hologic Discovery QDR 4500. TBS measurements were performed using the TBS iNsight software version 2.
Bone strain index for fracture risk assessment in older men-the prospective STRAMBO study.
Eur J Endocrinol
November 2024
INSERM UMR 1033, Hôpital E. Herriot, 69437 Lyon, France.
Objective: Bone strain index (BSI) is a noninvasive index of bone strength assessed on lumbar spine and femur dual energy X-ray absorptiometry scans using the finite-element method. In this study, we assess the link of the lumbar spine and hip BSI with fracture risk in older men.
Design: Prospective cohort study.
High prevalence of osteoporosis among virally suppressed older people (≥60 years) living with HIV.
HIV Med
November 2024
Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, UK.
Article Synopsis
- The study assessed bone mineral density (BMD) in older HIV-positive individuals in Kenya as they enrolled in a clinical trial, focusing on participants aged 60 and above.
- A total of 296 Black African participants were included, with findings indicating a high prevalence of osteoporosis (37.5%) and osteopenia (47.3%) among them, alongside calculated fracture risks.
- The research highlighted challenges in diagnosing osteoporosis due to limited access to dual-energy x-ray absorptiometry (DXA) in Kenya, showing a negative correlation between fracture risk probabilities and femoral neck BMD.
Effects of bisphosphonates combined with calcitriol in treating osteoporosis induced by endocrine therapy for breast cancer.
Am J Transl Res
October 2024
Department of Head and Neck Surgery of Mammary Gland and Thyroid Gland, Yuebei People's Hospital Shaoguan 512000, Guangdong, China.
Objective: To evaluate the therapeutic effects of bisphosphonates (specifically zoledronic acid) combined with calcitriol on osteoporosis (OP) induced by endocrine therapy for breast cancer.
Methods: A retrospective analysis was performed on the clinical data from 150 patients with OP induced by endocrine therapy for breast cancer, who were admitted to Yuebei People's Hospital from May 2020 to March 2022. Patients were divided into two groups based on their treatment regimens: 78 patients received oral calcitriol alone (control group), and 72 patients received zoledronic acid combined with calcitriol (study group).
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