We simulated the way that pelvic floor muscles (PFM) generate zonal compression on the vagina and urethra in order to maintain urinary continence. Raw data were obtained using a probe to map the distribution of vaginal closure forces. Simulation model was made using ordinary Spring-mass model. The biomechanical properties are applied to the spring of the model. We simulated four models that are applied to asymptomatic subjects as controls and patients based on information obtained from the measured force maps using a vaginal probe. PFM values are measured when subjects are relaxed and during voluntary PFM contraction. Results show that simulation clearly distinguished between controls and patents and demonstrates that in the controls, after a period of 0.075 sec from the time when the rest force was added, the model was deformed to a neutral shape, and after another period of 0.075 sec from the time when the contract force was added at intervals of 0.001 sec, the closure force reaches maximum. The results render the simulation of the vaginal wall deformations that was obtained directly by the force maps. It shows that in controls the wall model is significantly deformed compared to that from the patient's model. In this research we simulated the response of the vaginal walls using spring mass model and the force maps of vaginal closure forces applied to control subjects and patients. The process of deformation of the vaginal wall is thus visualized demonstrating the relative pathologic differences between the two groups.
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Sci Rep
December 2024
Department of Medical Microbiology and Infection Prevention, Amsterdam UMC - Location AMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Vaginal reconstruction is necessary for various congenital and acquired conditions, including vaginal aplasia, trauma, tumors, and gender incongruency. Current surgical and non-surgical treatments often result in significant complications. Decellularized vaginal matrices (DVMs) from human tissue offer a promising alternative, but require effective sterilization to ensure safety and functionality.
View Article and Find Full Text PDFBMC Surg
December 2024
Department of Obstetrics & Gynecology, Peking University Third Hospital, No. 49 Huayuan North Road, Haidian District, Beijing, 100191, China.
Introduction And Hypothesis: To investigate the mid-term outcomes of transvaginal repair for moderate-severe cystocele using autologous fascia lata harvested through a single small incision.
Methods: Between February and October 2022, 35 patients with moderate to severe cystocele undergoing transvaginal repair with autologous fascia lata were included. Patient demographics and perioperative data were collected, with follow-ups through outpatient visits or phone calls.
Cureus
November 2024
Urology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University) Pune, Pune, IND.
Urethrovaginal fistulas are rare complications often arising from urethrovaginal injuries commonly due to obstetrical trauma, urethral surgeries, pelvic fractures, or neoplastic treatments. Here, we present a unique case involving a 23-year-old female patient with a large urethrovaginal fistula and complete anterior vaginal wall sloughing following prolonged obstructed labor. Nine months post-cesarean, she reported urine leakage via the vagina upon catheter removal, which intensified in an erect posture.
View Article and Find Full Text PDFArch Gynecol Obstet
December 2024
Department of Gynecology, First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Dong Road, ErQi District, Zhengzhou, 450001, China.
Background: Stress urinary incontinence (SUI) is prevalent among women, often occurring alongside anterior vaginal wall prolapse. This study compares the efficacy and safety of an improved vaginal wall repair technique with pubocervical fascia fixation versus standard anterior colporrhaphy for treating SUI in women with anterior vaginal wall prolapse.
Methods: A single-centre, parallel-group, randomised controlled trial was conducted between September 2021 and June 2024.
Front Oncol
December 2024
Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
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