AI Article Synopsis
- The study investigates DNA methylation patterns in human fetuses with neural tube defects (NTD) compared to controls, highlighting significant differences in 5-methyl cytosine (5mC) levels in the brain, skin, and heart tissues.
- The research finds that NTD fetuses show reduced 5mC in brain DNA and abnormal methylation trends in liver and kidney compared to normal fetuses.
- Additionally, lower maternal serum folate levels were linked to these methylation changes, suggesting a potential connection between folate deficiency and the occurrence of NTDs.
Article Abstract
This study compares the density and tissue-specific distribution of 5-methyl cytosine (5mC) in genomic DNA from human fetuses with or without neural tube defects (NTD) and examines whether low maternal serum folate is a possible correlate and/or risk factor for NTD. The results demonstrate significant hypomethylation of brain genomic DNA in NTD fetuses relative to controls (P<.01), as well as relative hypermethylation of skin and heart in NTD fetuses. In normal fetuses, the level of 5mC in liver genomic DNA decreased from fetal week 18 to 28 and increased over the same developmental period in kidney genomic DNA, but these trends were absent in genomic DNA from NTD fetuses. Mean maternal serum folate was significantly lower in NTD fetuses than in controls (P<.01), and maternal serum folate correlated with density of 5mC in genomic brain DNA from NTD fetuses (r=0.610). The results indicate that aberrant DNA methylation in NTD may be due to maternal folate deficiency and may be involved in the pathogenesis of NTD in humans.
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| http://dx.doi.org/10.1016/j.jnutbio.2010.10.003 | DOI Listing |
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