AI Article Synopsis
- The review focuses on the significance of telomeres and telomerase as potential targets for cancer treatment, highlighting ongoing research and clinical trials in this area.
- It emphasizes the connection between dysfunctional telomeres and cellular aging, explaining how this process can initially prevent the development of cancerous immortalized cells.
- The discussion includes various strategies for targeting telomeres and telomerase in cancer therapy, such as using telomerase in immunotherapy, gene therapy with oncolytic viruses, and targeted treatment with small oligonucleotides like Imetelstat.
Article Abstract
The role of telomeres and telomerase as a target for cancer therapeutics is an area of continuing interest. This review is intended to provide an update on the field, pointing to areas in which our knowledge remains deficient and exploring the details of the most promising areas being advanced into clinical trials. Topics that will be covered include the role of dysfunctional telomeres in cellular aging and how replicative senescence provides an initial barrier to the emergence of immortalized cells, a hallmark of cancer. As an important translational theme, this review will consider possibilities for selectively targeting telomeres and telomerase to enhance cancer therapy. The role of telomerase as an immunotherapy, as a gene therapy approach using telomerase promoter driven oncolytic viruses and as a small oligonucleotide targeted therapy (Imetelstat) will be discussed.
Download full-text PDF |
Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370414 | PMC |
| http://dx.doi.org/10.1111/j.1582-4934.2011.01279.x | DOI Listing |
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