SC1 is an immunoglobulin superfamily cell adhesion molecule purified from the Gallus gallus spinal cord. SC1 is present in embryonic tissues and plays a role in chick development through its cell adhesive property. Interestingly, increased SC1 expression is observed in some sporadic tumours of the chicken, including Marek's disease-induced lymphomas and in nephroblastomas. To elucidate the possible functions of SC1 in tumour progression in the chicken, SC1 cDNA was introduced into the endogenous SC1-negative Marek's disease-derived chicken lymphoblastoid cell line MDCC-MSB1, and subsequently the metastatic potentials of these cell lines were analysed. The in vitro analyses revealed that the SC1-transfected MDCC-MSB1 cells were enhanced in their adhesive and migratory activities in the presence of the SC1 proteins. In addition, the metastatic potential of the SC1-transfected MDCC-MSB1 cells to the lung was enhanced after intravenous implantation into chickens. These findings suggest that the expression of SC1 contributes to the malignancy and metastatic properties of chicken Marek's disease-induced lymphomas.
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http://dx.doi.org/10.1080/03079457.2010.541901 | DOI Listing |
J Innate Immun
December 2024
Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Medicine, Meharry Medical College, Nashville, Tennessee, USA.
Introduction: Natural killer (NK) cells are innate lymphoid cells capable of directly killing target cells while modulating immune effector responses. Despite their multifunctional capacities, a limited understanding of their plasticity and heterogeneity has impeded progress in developing effective NK cell-based cancer therapies. In this study, we investigated NK cell tissue heterogeneity in relation to their phenotype and effector functions against lung tumors.
View Article and Find Full Text PDFbioRxiv
November 2024
Department of Biological Sciences, Hunter College, City University of New York, New York, NY, 10065 USA.
Cell cycle progression is tightly controlled by the regulated synthesis and degradation of Cyclins, such as Cyclin A and Cyclin B, which activate CDK1 to trigger mitosis. Mutations affecting Cyclin regulation are often linked to tumorigenesis, making the study of cyclin mRNA regulation critical for identifying new cancer therapies. In this study, we demonstrate via super-resolution microscopy that and mRNAs associate with Bruno 1 and Cup in nurse cells.
View Article and Find Full Text PDFJ Cell Mol Med
October 2024
Inserm UMRS_1131, Institut de Recherche Saint-Louis, Université de Paris, Paris, France.
Myeloproliferative neoplasms (MPNs) are characterized by an increased production of blood cells due to the acquisition of mutations such as JAK2. TGF-β, whose secretion is increased in MPN patients, is known to negatively regulate haematopoietic stem cell (HSC) proliferation. Using an isogenic JAK2 or JAK2 wild-type UT-7 cell line we observed that JAK2 cells resist to TGF-β antiproliferative activity.
View Article and Find Full Text PDFmBio
November 2024
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Int J Neuropsychopharmacol
October 2024
Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, UK.
Background: Understanding the precise mechanisms of ketamine is crucial for replicating its rapid antidepressant effects without inducing psychomimetic changes. Here, we explore whether the antidepressant-like effects of ketamine enantiomers are underscored by protection against cytokine-induced reductions in hippocampal neurogenesis and activation of the neurotoxic kynurenine pathway in our well-established in vitro model of depression in a dish.
Methods: We used the fetal hippocampal progenitor cell line (HPC0A07/03C) to investigate ketamine's impact on cytokine-induced reductions in neurogenesis in vitro.
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