AI Article Synopsis
- This study investigates how topical prostaglandin antiglaucoma drugs, such as bimatoprost, latanoprost, and travoprost, may lead to a deepening of the upper eyelid sulcus in patients.
- It analyzed preaponeurotic orbital fat from 18 eyes of 11 patients, revealing significant differences in adipocyte density between treated and untreated eyes, particularly in those using bimatoprost and travoprost.
- The findings suggest that the atrophy of fat tissue in the upper eyelid can be a contributing factor to the observed changes in eyelid appearance among users of these glaucoma medications.
Article Abstract
Purpose: To confirm the possible mechanism by which topical prostaglandin antiglaucoma drugs cause a deep superior sulcus.
Methods: Among patients who used bimatoprost (Lumigan), latanoprost (Xalatan), or travoprost (Travatan) and who developed a deep upper lid sulcus, 18 eyes of 11 patients (mean age, 58.2 ± 8.9 years) were studied. Seven patients were binocular users of one of the eye drops and four were monocular users. Preaponeurotic orbital fat was obtained, and the mean adipocyte density compared.
Results: In the four monocular users, mean adipocyte density of treated eyes was 1758.21 ± 158.15 cells/mm(2), and that of untreated eyes was 1258.73 ± 127.54 cells/mm(2). This difference was statistically significant (P = 0.04), suggesting that the adipocytes were atrophied in the treated eyes. The mean adipocyte density of the bimatoprost group was 2073.35 ± 184.89 cells/mm(2), that of the travoprost group was 1623.46 ± 218.99 cells/mm(2), and that of the latanoprost group was 1468.20 ± 113.44 cells/mm(2). The densities of the bimatoprost and travoprost groups, but not of the latanoprost group (P = 0.75), were significantly different from that of the untreated group (P < 0.001).
Conclusions: Fat atrophy can be considered a mechanism of upper eyelid sulcus deepening in patients using topical prostaglandin analogs.
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| http://dx.doi.org/10.1007/s10384-010-0904-z | DOI Listing |
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