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An Evaluation of 90Y Bremsstrahlung SPECT Image Quality in the Presence of 99mTc: A Technical Perspective on Same-Day Radioembolization.
Curr Oncol
November 2024
Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
In same-day radioembolization, 99mTc-MAA SPECT/CT, 90Y radioembolization, and post-treatment 90Y SPECT/CT procedures are conducted on the same-day, resulting in a dual-isotope environment of 90Y and 99mTc during post-treatment imaging. This study aimed to quantify the impact of 99mTc on 90Y bremsstrahlung-SPECT/CT image quality and to establish an optimised imaging protocol for both clinical practice, and with advanced reconstruction techniques. Utilising a NEMA IQ phantom, contrast recovery coefficients (CRCs) were measured to evaluate the 90Y image quality degradation caused by 99mTc.
View Article and Find Full Text PDFA Combinatorial Approach with Microneedle Pretreatment and Thermosensitive Gel Loaded with Rivastigmine Lipid Nanoparticle Formulation Enables Brain Delivery via the Trigeminal Nerve.
ACS Appl Mater Interfaces
December 2024
Department of Chemistry, IPB University, Bogor 16680, West Java Indonesia.
Article Synopsis
- Alzheimer's disease leads to cognitive decline and increased care needs; Rivastigmine (RV) is a key treatment limited by the blood-brain barrier (BBB).
- A new method using polymeric microneedles (PMN) and a solid lipid nanoparticle-RV-loaded thermosensitive gel (PMN-SLN-RV-TG) shows potential for better brain delivery compared to traditional methods.
- The study found that PMN-SLN-RV-TG has improved penetration and pharmacokinetic parameters, yielding a higher brain-to-blood ratio and demonstrating safety for brain tissue, indicating a promising alternative for Alzheimer's treatment.
Incidental Renal Infarction on imaging for Abdominal Aortic Aneurysm.
J Pak Med Assoc
November 2024
Nuclear Medicine Department, East Kent University Hospitals NHS Foundation Trust, UK.
Article Synopsis
- A 59-year-old man undergoing surveillance for an abdominal aortic aneurysm and peripheral artery disease was evaluated through a CT Angiogram of the aorta.
- The scan revealed a 6.2cm abdominal aortic aneurysm with significant thrombus, occluded arteries, and calcified stenosis in key blood vessels.
- A Tc-99m DMSA renal scan was performed to assess the extent of kidney infarction and to evaluate the functional differences between the kidneys.
High-Flow Nasal Aerosol Therapy; Regional Aerosol Deposition and Airway Responsiveness.
J Aerosol Med Pulm Drug Deliv
December 2024
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Stony Brook University Medical Center, Stony Brook, New York, USA.
Article Synopsis
- In a study involving 12 subjects with moderate to severe obstructive lung disease (OLD), researchers compared aerosol deposition and airway responsiveness using traditional nebulization and high-flow nasal cannula (HFNC) therapy.
- Results showed that while traditional inhalation resulted in a central to peripheral deposition ratio, the use of HFNC significantly increased peripheral drug delivery and improved spirometry measures, indicating better lung function.
- The study also noted that systemic effects were minimal, suggesting that nasal absorption of the aerosol medication was limited, and different mechanisms governed deposition when comparing traditional nebulization to HFNC methods.
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