Objective: To identify the proportion of major structural noncardiac anomalies identified with congenital heart defects (CHDs).
Study Design: Records of infants with CHDs in the Metropolitan Atlanta Congenital Defects Program who were born during the period 1968 through 2005 were classified as having isolated, syndromic, multiple CHD (ie, having an unrecognized pattern of multiple congenital anomalies or a recognized pattern of multiple congenital anomalies of unknown etiology), or laterality defects. Frequencies of associated noncardiac anomalies were obtained.
Results: We identified 7984 live-born and stillborn infants and fetuses with CHDs. Among them, 5695 (71.3%) had isolated, 1080 (13.5%) had multiple, 1048 (13.1%) had syndromic, and 161 (2.0%) had laterality defects. The percentage of multiple congenital anomalies was highest for case with atrial septal defects (18.5%), cardiac looping defects (17.2%), and conotruncal defects (16.0%), and cases with atrioventricular septal defects represented the highest percentages of those with syndromic CHDs (66.7%).
Conclusions: Including those with syndromes and laterality defects, 28.7% of case infants with CHDs had associated major noncardiac malformations. Thus, infants with CHDs warrant careful examination for the presence of noncardiac anomalies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpeds.2010.12.051 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fragmented QRS complexes in electrocardiogram and their relationship with somatic symptoms in postmenopausal women.
Menopause
January 2025
From the Ankara Etlik City Hospital, Obstetrics and Gynecology Hospital, Ankara, Turkey.
Objective: Menopause significantly impacts cardiovascular health, yet the relationship between myocardial abnormalities and noncardiac symptoms in postmenopausal women remains underexplored. This study aims to investigate the association between fragmented QRS waves (fQRS) positivity on electrocardiograms (ECG) and somatic symptoms in postmenopausal women.
Methods: We included 623 postmenopausal women attending a menopause clinic for routine annual gynecological examinations.
Clinical approach to palpitations in pregnancy.
Clin Med (Lond)
December 2024
Department of Cardiology, Barts Heart Centre and Newham University Hospital, Barts Health NHS Trust, Honorary Senior Lecturer, William Harvey Research Institute, Queen Mary University of London. Electronic address:
Palpitations are common in pregnancy and warrant investigation. Palpitations may be caused by non-cardiac and cardiac causes. Patients with structural or functional abnormalities or inherited cardiovascular disease are more likely to develop arrhythmia, especially during pregnancy when the mother's body undergoes extensive physiological adaptations, which further contribute to an increased arrhythmia risk.
View Article and Find Full Text PDFPreventing, identifying and managing myocardial injury after non cardiac surgery - a narrative review.
Curr Opin Anaesthesiol
February 2025
Center for OUTCOMES RESEARCH and Department of Anesthesiology, UTHealth, Houston, Texas.
Purpose Of Review: There is mounting and convincing evidence that patients with postoperative troponin elevation, with or without any clinical symptoms, are at higher risk for both, short- and long-term morbidity and mortality. Myocardial injury after noncardiac surgery (MINS) is a relatively newly described syndrome, and the pathogenesis is not fully understood yet. MINS is now an established syndrome and multiple guidelines address potential etiologies, triggers, as well as preventive and management strategies.
View Article and Find Full Text PDFIntroduction: Abdominal aortic aneurysms (AAAs) and peripheral arterial and aortic diseases (PAADs) are associated with increased risk of myocardial injury after noncardiac surgery (MINS).
Objectives: Our aim was to evaluate whether preoperative transthoracic echocardiography (TTE) abnormalities are linked to MINS in patients undergoing open vascular surgeries involving the abdominal aorta due to AAA and / or PAAD.
Patients And Methods: We analyzed a retrospective cohort of consecutive patients who underwent open abdominal aortic surgery due to infrarenal AAA and / or aortoiliac occlusive disease in a single tertiary center.
Characterization of a novel ovine model of hypertensive heart failure with preserved ejection fraction.
Am J Physiol Heart Circ Physiol
December 2024
Manaaki Manawa - The Centre for Heart Research, Department of Physiology, University of Auckland, Auckland, New Zealand.
Article Synopsis
- There is a significant need for better animal models to study heart failure with preserved ejection fraction (HFpEF), as current models do not adequately represent the condition and hinder research on treatments.
- A new model using older female sheep with chronic hypertension was developed, showing key characteristics of HFpEF, such as higher blood pressure and signs of heart dysfunction without obvious systolic impairment.
- This sheep model also exhibited decreased exercise capacity, making it a promising tool for further research to understand HFpEF and potentially improve therapy options.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!