Ion flow in stria vascularis and the production and regulation of cochlear endolymph and the endolymphatic potential.

Hear Res

The Auditory Laboratory, Physiology M311, The University of Western Australia, 35 Stirling Highway, Crawley 6009, Australia.

Published: July 2011

AI Article Synopsis

Article Abstract

This paper reviews some of what is known about ion transport through the cells of the mammalian stria vascularis, and discusses how the endolymph and endocochlear potential in scala media are produced by the stria's main cell types. It discusses the role of each cells' ion transport proteins from an engineering perspective, and the advantages and disadvantages in using the different transport proteins in the different cells to perform their different roles. To aid this discussion, the use of spreadsheet analysis in the modelling of ion transport in single cells and homogenous epithelia is outlined, including the current-voltage (IV) characteristics of the three main categories of transport proteins (pores, ports and pumps), and the constraint equations that apply under various conditions (the voltage or ionic steady states in the open- and closed-circuit conditions). Also discussed are the circulation of K(+) within the cochlea, and the chloride, salt and water balance of scala media and stria vascularis, and what transport processes may be required to maintain such a balance.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heares.2011.01.010DOI Listing

Publication Analysis

Top Keywords

stria vascularis
12
ion transport
12
transport proteins
12
scala media
8
transport
6
ion
4
ion flow
4
flow stria
4
vascularis production
4
production regulation
4

Similar Publications

Background: Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide. Current solutions for SNHL, including hearing aids, cochlear implants, and hearing assistive devices, do not provide consistent results and fail to address the underlying pathology of hair cell and ganglion cell damage. Stem cell therapy is a cornerstone in regenerative medicine.

View Article and Find Full Text PDF

Objective: This study aimed to attenuate cochlear inflammation following noise-induced hearing loss by targeting IL-1. We evaluated the effectiveness of IL-1 inhibition through auditory and histological assessments in an animal model.

Study Design: Experimental animal study.

View Article and Find Full Text PDF

Background: Hearing loss affects over 10% of the global population. Inflammation is a key factor in hearing loss caused by noise, infection, and aging, damaging various hearing-related tissues (e.g.

View Article and Find Full Text PDF

Background: Melanocytes in the hair and melanocytes in the stria vascularis of the inner ear have common origins. Many congenital and acquired disorders of cutaneous pigmentation have auditory abnormalities. There is a paucity of studies on the auditory associations of early graying.

View Article and Find Full Text PDF
Article Synopsis
  • A new case shows unusual cochlear enhancement on MRI in a 3-year-old with ND and normal hearing, which hasn't been documented before.
  • Future research should investigate the timing of cochlear changes and their relationship to hearing loss, as this could help with gene therapy candidates and offer clues about treatment outcomes.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!