Interference is a major source of short-term errors of memory. The present investigation explores the relationship between two important forms of interference: proactive interference (PI), induced by the need to reject recently studied items no longer relevant to task performance, and semantic interference (SI), induced by the need to reject lures sharing a meaningful relationship with current memoranda. We explore the possibility that shared cognitive control processes are recruited to resolve both forms of interference. In Experiment 1, we find that the requirement to engage in articulatory suppression during the retention interval of tasks that induce either PI or SI increases both forms of interference similarly and selectively. In Experiment 2, we develop a task to examine PI and SI within the same experimental context. The results show interactive effects between factors that lead to the two forms of interference. Taken together, these findings support contextual-cuing models of short-term remembering (Nairne, Annual Review of Psychology, 53, 53-81 2002), where the context in which retrieval occurs can influence susceptibility to interference. Lastly, we discuss several theoretical hypotheses concerning the cognitive control processes that are recruited to resolve SI and PI in short-term remembering.
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http://dx.doi.org/10.3758/s13421-011-0072-5 | DOI Listing |
Front Pharmacol
December 2024
College of Pharmacy, Jinan University, Guangzhou, China.
Bone homeostasis encompasses two interrelated aspects: bone remodeling and cartilage metabolism. Disruption of bone homeostasis can lead to the development of metabolic bone diseases such as osteoporosis and osteoarthritis. The maintenance of bone homeostasis is a complex process that does not solely rely on the functions of the bone tissue itself.
View Article and Find Full Text PDFChem Res Toxicol
January 2025
SB RAS Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Avenue, Novosibirsk 630090, Russia.
Biological polyamines, such as spermine, spermidine, and putrescine, are abundant intracellular compounds mostly bound to nucleic acids. Due to their nucleophilic nature, polyamines easily react with apurinic/apyrimidinic (AP) sites, DNA lesions that are constantly formed in DNA by spontaneous base loss and as intermediates of base excision repair. A covalent intermediate is formed, promoting DNA strand cleavage at the AP site, and is later hydrolyzed regenerating the polyamine.
View Article and Find Full Text PDFAdv Mater
January 2025
Department of Chemical Engineering & Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.
Colloidal drug aggregates (CDAs) are challenging in drug discovery due to their unpredictable formation and interference with screening assays. These limitations are turned into a strategic advantage by leveraging CDAs as a drug delivery platform. This study explores the deliberate formation and stabilization of CDAs for local ocular drug delivery, using a modified smallmolecule glaucoma drug.
View Article and Find Full Text PDFBMC Ecol Evol
January 2025
Botany & Microbiology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
Background: The destructive human activities, encroachment of natural habitats, and hyperarid climate threaten the wild flora of the unprotected mountainous areas facing the Gulf of Suez, Egypt. So, this study aims to revise and give an updated systematic status of the flowering plants growing there to conserve and utilize valuable biodiversity.
Results: This study showed the presence of 136 species, including 7 sub-species of vascular plants, 12 species of monocots, and 124 species dicots belonged to 98 genera and 37 families.
J Mater Chem B
January 2025
State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
The construction of selectively activated prodrugs serves as a crucial strategy for reducing the adverse effects associated with disease treatment. Cascade self-assembled visual prodrugs have been applied to the construction of selective activated prodrugs with low background interference and fluorescence. In this work, we rationally designed an anticancer theranostic prodrug (CM-PPT) consisting of an anticancer drug podophyllotoxin, a fluorescent dye precursor, and an HO trigger boronate ester group, which could be activated by HO oxidation, thereby releasing active anticancer molecules and forming fluorescent fragments concurrently.
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