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Comparative lipid profiling reveals the differential response of distinct lipid subclasses in blast and blunt-induced mild traumatic brain injury.
Exp Neurol
January 2025
Traumatic Brain Injury & Metabolomics Department, DRDO, Institute of Nuclear Medicine and Allied Sciences (INMAS), S. K Mazumdar Road, Timarpur, New Delhi 110054, India. Electronic address:
Head trauma from blast exposure is a growing health concern, particularly among active military personnel, and is considered the signature injury of the Gulf War. However, it remains elusive whether fundamental differences exist between blast-related traumatic brain injuries (TBI) and TBI due to other mechanisms. Considering the importance of lipid metabolism associated with neuronal membrane integrity and its compromise during TBI, we sought to find changes in lipidomic profiling during blast or blunt (Stereotaxically Controlled Contusison-SCC)-mediated TBI.
View Article and Find Full Text PDFRemote Ischemic Post-Conditioning (RIC) Mediates Anti-Inflammatory Signaling via Myeloid AMPKα1 in Murine Traumatic Optic Neuropathy (TON).
Int J Mol Sci
December 2024
Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center (SJHMC), Phoenix, AZ 85013, USA.
Traumatic optic neuropathy (TON) has been regarded a vision-threatening condition caused by either ocular or blunt/penetrating head trauma, which is characterized by direct or indirect TON. Injury happens during sports, vehicle accidents and mainly in military war and combat exposure. Earlier, we have demonstrated that remote ischemic post-conditioning (RIC) therapy is protective in TON, and here we report that AMPKα1 activation is crucial.
View Article and Find Full Text PDFPatterns of Brain Injury and Clinical Outcomes Related to Trauma from Collisions Involving Motor Vehicles.
J Clin Med
December 2024
Department of Surgery, NYC Health and Hospitals, Elmhurst Hospital Center, New York, NY 11373, USA.
: Despite improvements in technology and safety measures, injuries from collisions involving motor vehicles (CIMVs) continue to be prevalent. Therefore, our goal is to investigate the different patterns of head injuries associated with CIMVs. : This is a single-center, retrospective study of patients with motor vehicle-related trauma between 1 January 2016-31 December 2023.
View Article and Find Full Text PDFAssessment of Donkey Welfare at Slaughter in Ghana.
Animals (Basel)
December 2024
Animal Welfare Science and Ethics Group, Department of Pathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield AL9 7TA, UK.
Donkey slaughter in West Africa has received limited scientific attention, despite increasing over recent years. This study aimed to explore factors affecting donkey welfare, both ante-mortem and at slaughter, in the Upper East region of Ghana. A total of 134 donkeys at five different slaughter points were assessed using animal-based indicators.
View Article and Find Full Text PDFUndetermined Ruptured Low-Grade Appendiceal Mucinous Neoplasm Following High-Energy Blunt Abdominal Trauma Requiring Emergency Laparotomy.
Clin Case Rep
January 2025
Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences Okayama University Okayama Japan.
Blunt abdominal trauma causing intraperitoneal injury and/or bleeding can be life-threatening, requiring immediate intervention. Diagnosing these cases can be challenging, especially when pre-existing conditions are involved. Low-grade appendiceal mucinous neoplasm (LAMN) is a rare tumor of the appendix that can lead to pseudomyxoma peritonei.
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