Autoimmune clustering: sweet syndrome, Hashimoto thyroiditis, and psoriasis.

J Clin Rheumatol

Division of General Internal Medicine, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Published: March 2011

AI Article Synopsis

  • Acute febrile neutrophilic dermatosis (AFND), also known as Sweet syndrome, is marked by symptoms like fever, increased neutrophils, and painful red skin lesions with neutrophil infiltration in the skin.
  • The report discusses a unique case of AFND occurring alongside chronic lymphocytic thyroiditis (Hashimoto thyroiditis) and psoriasis, making it the first documented instance of such a combination in the U.S. and only the third globally.
  • The authors suggest that the rare combination of these conditions may indicate a shared underlying cause, potentially related to dysfunction in CD4(+) T-cells.

Article Abstract

Acute febrile neutrophilic dermatosis (AFND; Sweet syndrome) is characterized by a constellation of symptoms and findings: fever, neutrophilia, and tender erythematous skin lesions that typically show an upper dermal infiltrate of mature neutrophils. Whereas some cases are idiopathic, others have been associated with a variety of disorders. In this report, we describe the occurrence of AFND with chronic lymphocytic thyroiditis (Hashimoto thyroiditis) and preexisting psoriasis. This is the first case report of the association of chronic lymphocytic thyroiditis with AFND from the United States and only the third reported in the world's literature. Because the coexistence of these disorders is rare, an underlying common pathogenic mechanism is a possibility. We postulate this to be CD4(+) T-cell dysfunction.

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Source
http://dx.doi.org/10.1097/RHU.0b013e31820e624fDOI Listing

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