AI Article Synopsis
- Susac syndrome (SS) is characterized by a combination of vision loss, hearing loss, and brain dysfunction caused by autoimmune damage to blood vessel linings.
- The case study focuses on a 25-year-old woman who experienced confusion, mobility issues, and sensory loss during her 20th week of pregnancy, leading to specific findings like retinal artery occlusions and brain lesions.
- She was treated with various medications, including corticosteroids and immunotherapy, with adjustments made to protect her unborn child during recurrent disease episodes.
Article Abstract
Susac syndrome (SS) consists of a triad of vision loss, hearing loss, and encephalopathy due to autoimmune-mediated vascular endothelial injury. Herein we describe a 25-year-old previously healthy woman who presented at 20 weeks' gestation with symptoms of confusion, difficulty walking, and vision and hearing loss. She had branch-retinal artery occlusions on funduscopic examination, and sensorineural hearing loss. Additionally, non-contrast enhanced brain magnetic resonance imaging showed multiple white matter and callosal lesions consistent with ischemia. She was treated initially with aspirin, corticosteroids, and intravenous immunoglobulin with early improvement, although recurrent disease was treated with cyclophosphamide and rituximab after induction of premature delivery (at 35 weeks' gestation) to spare the fetus possible toxicity. We additionally discuss a general overview of SS, what is known about pregnancy and this disease, and issues regarding diagnostic and treatment approaches for SS during pregnancy.
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| http://dx.doi.org/10.1097/RHU.0b013e31820e77c3 | DOI Listing |
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