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Objectives: Urinalysis is widely used and is also frequently requested in emergency situations for screening hypovolemia, urinary tract infections, diabetes, ketoacidosis and hematuria. Our aim was to evaluate the impact of reporting urinary sediment in emergency department specimens with the Sysmex UN system.

Methods: We evaluated urinalyses requested by the emergency department over a three-month period and examined red blood cell count interference, compared leukocyte esterase dipsticks to cytofluorimetric leukocyte count and nitrites to cytofluorimetric bacterial count.

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Blood matters: the hematological signatures of Coronavirus infection.

Cell Death Dis

November 2024

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.

Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well understood. Employing a dual-modality approach, we integrated findings from a Murine Hepatitis Virus (MHV) infection model with corroborative clinical data to investigate the pervasive reach of Coronaviruses.

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An Overlap of Anticoagulant-Related and IgA Nephropathy: A Case Report.

Glomerular Dis

August 2024

Department of Pathology Arkana Lab Little Rock, Little Rock, AR, USA.

Article Synopsis
  • Anticoagulant-related nephropathy (ARN) is becoming more recognized as a cause of acute kidney injury (AKI), especially in patients using warfarin, and now also needs scrutiny for direct oral anticoagulants (DOACs).
  • A case study showed a 64-year-old male with paroxysmal atrial fibrillation treated with DOACs, presenting with heart failure and AKI, which was linked to kidney damage and underlying IgA nephropathy.
  • The findings highlight the need for clinicians to be vigilant about the potential risk of ARN in patients on DOACs, especially when they exhibit symptoms of AKI, emphasizing early diagnosis for better patient outcomes.
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Granulomatosis with polyangiitis (GPA) is a rare autoimmune disease with multi-system involvement. It involves the upper respiratory tract, lungs and kidneys. A 36-year-old female patient presented to a tertiary care referral hospital in Central India in 2023 with complaints of low-grade fever, dry cough and loss of appetite initially followed by dyspnoea, purpuric skin lesions, right lower limb swelling with pain and redness.

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Glomerulonephritis (GN) encompasses a heterogeneous group of disease processes. It accounts for approximately 20% of chronic kidney disease and is the second most common cause of kidney failure worldwide. A study of a cohort of Medicare patients found that approximately 1.

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