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Immune Regulation of Goblet Cell and Mucus Functions in Health and Disease.
Annu Rev Immunol
January 2025
2Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden; email:
The mucosal surfaces of the body are the most vulnerable points for infection because they are lined by single or multiple layers of very active epithelial cells. The main protector of these cells is the mucus system generated by the specialized goblet cells secreting its main components, the gel-forming mucins. The organization of the mucus varies from an attached mucus that is impenetrable to bacteria in the large intestine to a nonattached, more penetrable mucus in the small intestine and airways.
View Article and Find Full Text PDFSoft palate angle and basihyoid depth increase with tongue size and with body condition score in horses.
Equine Vet J
January 2025
University of Liverpool, Leahurst Campus, Neston, UK.
Background: Obesity has been associated with human obstructive sleep apnoea and canine brachycephalic obstructive airway syndrome. The effect of body condition score (BCS) on structures of the oropharynx, nasopharynx and upper airway of the horse has not been investigated.
Objectives: To investigate the effect of BCS on tongue measurements, soft palate angle and basihyoid depth in horses.
Seasonal effect of PM exposure in patients with COPD: a multicentre panel study.
Environ Sci Process Impacts
January 2025
Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-Gil, Songpa-gu, Seoul 05505, South Korea.
: Exposure to particulate matter <2.5 μm (PM) is linked to chronic obstructive pulmonary disease (COPD), but most studies lack individual PM measurements. Seasonal variation and their impact on clinical outcomes remain understudied.
View Article and Find Full Text PDFAdvanced Lung-on-a-Chip Technology: Mimicking the Complex Human Lung Microenvironment.
Int J Biol Sci
January 2025
Division of Science Education, Kangwon National University, 24341, Republic of Korea.
Intricate crosstalk among various lung cell types is crucial for orchestrating diverse physiological processes. Traditional two-dimensional and recent three-dimensional (3D) assay platforms fail to precisely replicate these complex communications. Many lung models do not effectively reflect the multicellular complexity of lung tissue.
View Article and Find Full Text PDFImmune dysregulation as a driver of bronchiolitis obliterans.
Front Immunol
January 2025
Department of Respiration, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, Guangdong, China.
Bronchiolitis obliterans (BO) is a disease characterized by airway obstruction and fibrosis that can occur in all age groups. Bronchiolitis obliterans syndrome (BOS) is a clinical manifestation of BO in patients who have undergone lung transplantation or hematopoietic stem cell transplantation. Persistent inflammation and fibrosis of small airways make the disease irreversible, eventually leading to lung failure.
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