SAR study of the piperidine moiety in a series of quinolizidinone carboxylic acid M(1) positive allosteric modulators was examined. While the SAR was generally flat, compounds were identified with high CNS exposure to warrant additional in vivo evaluation.
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| http://dx.doi.org/10.1016/j.bmcl.2011.01.094 | DOI Listing |
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