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Effect of recombinant bovine granulocyte colony-stimulating factor treatment during the peripartum period on postpartum diseases, reproductive performance, and milk production in Holstein cattle.
Res Vet Sci
September 2024
Unit of Reproduction and Obstetrics, Dept. of Animal Pathology, Universidade de Santiago de Compostela, Faculty of Veterinary Medicine, Avda. Carballo Calero s/n, 27002 Lugo, Spain. Electronic address:
To boost the immune function around parturition, recombinant bovine granulocyte colony-stimulating factor (rbG-CSF) has been used to increase the number of neutrophils. Therefore, the aim of this study was to quantify the effect of rbG-CSF administration on the incidence of postpartum pathologies, reproductive performance, and milk production during the first three months of lactation. A total of 199 Holstein cows from one herd were included and were randomly allocated into two groups: Control (n = 103) and rbG-CSF (n = 96).
View Article and Find Full Text PDFAssociation between obstetrical anal sphincter injury and postpartum urinary retention: a contemporary nationwide cohort study.
Int Urogynecol J
December 2022
Division of Urogynaecology, Department of Obstetrics and Gynaecology, The Ottawa Hospital, Ottawa, ON, Canada.
Introduction And Hypothesis: Identification and prompt management of postpartum urinary retention after vaginal birth is essential to minimize long-term morbidity. Obstetrical anal sphincter injuries (OASIS) have been identified as a possible risk factor for urinary retention. The objective of this study was to estimate the association between OASIS and postpartum urinary retention and compare the length of hospital stay and cost of admission between postpartum patients who experienced urinary retention and those who did not.
View Article and Find Full Text PDFDifferential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration.
Dis Model Mech
November 2020
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Department of Translational Medicine, 67404 Illkirch, France
Skeletal muscle development and regeneration are tightly regulated processes. How the intracellular organization of muscle fibers is achieved during these steps is unclear. Here, we focus on the cellular and physiological roles of amphiphysin 2 (BIN1), a membrane remodeling protein mutated in both congenital and adult centronuclear myopathies (CNM), that is ubiquitously expressed and has skeletal muscle-specific isoforms.
View Article and Find Full Text PDFAmphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice.
Sci Transl Med
March 2019
IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), 67404 Illkirch, France.
Centronuclear myopathies (CNMs) are severe diseases characterized by muscle weakness and myofiber atrophy. Currently, there are no approved treatments for these disorders. Mutations in the phosphoinositide 3-phosphatase myotubularin (MTM1) are responsible for X-linked CNM (XLCNM), also called myotubular myopathy, whereas mutations in the membrane remodeling Bin/amphiphysin/Rvs protein amphiphysin 2 [bridging integrator 1 (BIN1)] are responsible for an autosomal form of the disease.
View Article and Find Full Text PDFTrauma and fear in Australian midwives.
Women Birth
February 2019
Menzies Health Institute Queensland, Griffith University, Australia. Electronic address:
Background: Relatively little is known about the extent of trauma and birth-related fear in midwives and how this might affect practice.
Aim: (1) Determine prevalence of birth related trauma and fear in midwives and associations with midwives' confidence to advise women during pregnancy of their birth options and to provide care in labour. (2) Describe midwives' experiences of birth related trauma and/or fear.
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