Endurance-type exercise training represents a cornerstone in type 2 diabetes treatment. However, the effects of prolonged continuous, endurance-type exercise on muscle fiber characteristics remain equivocal. Fifteen obese male type 2 diabetes patients (61 ± 6 years) participated in a 6-month continuous, endurance-type exercise program. Muscle biopsies were collected before, and after 2 and 6 months of intervention. Muscle fiber type-specific composition, size, and satellite cell (SC) and myonuclear content were determined by immunohistochemistry. Although continuous endurance-type exercise training lowered total body weight and reduced fat mass, no changes were observed in leg lean mass. At baseline, SC content was significantly lower in type II compared with type I muscle fibers. No change in SC content was observed after exercise training. Continuous endurance-type exercise training lowers fat mass, but it does not increase leg lean mass and/or modulate muscle fiber characteristics in type 2 diabetes patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mus.21891 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rating of Perceived Exertion: A Large Cross-Sectional Study Defining Intensity Levels for Individual Physical Activity Recommendations.
Sports Med Open
June 2024
Department of Sports Medicine, Charité - Universitätsmedizin Berlin, Philippstr. 13 Haus 11, 10115, Berlin, Germany.
Background: Physical inactivity is a growing risk factor worldwide, therefore getting people into sports is necessary. When prescribing physical activity, it is essential to recommend the correct training intensities. Cardiopulmonary exercise testing (CPX) enables precise determination of individuals' training intensities but is unavailable for a broad population.
View Article and Find Full Text PDFAltered skeletal muscle function and beneficial effects of exercise training in a rat model of induced pulmonary emphysema.
Acta Physiol (Oxf)
July 2024
PhyMedExp, INSERM, CNRS, Université de Montpellier, Montpellier, France.
Aim: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow obstruction and development of emphysema. Among the comorbidities associated with COPD, skeletal muscle dysfunction is known to affect exercise capacity and the survival rate of patients. Pulmonary rehabilitation (PR), via exercise training, is essential for COPD patients.
View Article and Find Full Text PDFVoluntary wheel running improves molecular and functional deficits in a murine model of facioscapulohumeral muscular dystrophy.
iScience
January 2024
Center for Genetic Medicine Research, Children's National Hospital, Washington, DC 20012, USA.
Endurance exercise training is beneficial for skeletal muscle health, but it is unclear if this type of exercise can target or correct the molecular mechanisms of facioscapulohumeral muscular dystrophy (FSHD). Using the FLExDUX4 murine model of FSHD characterized by chronic, low levels of pathological double homeobox protein 4 () gene expression, we show that 6 weeks of voluntary, free wheel running improves running performance, strength, mitochondrial function, and sarcolemmal repair capacity, while slowing/reversing skeletal muscle fibrosis. These improvements are associated with restored transcriptional activity of gene networks/pathways regulating actin cytoskeletal signaling, vascular remodeling, inflammation, fibrosis, and muscle mass toward wild-type (WT) levels.
View Article and Find Full Text PDF3'sialyllactose and 6'sialyllactose enhance performance in endurance-type exercise through metabolic adaptation.
Food Sci Nutr
October 2023
Vivaltes B.V. Bunnik The Netherlands.
Human milk oligosaccharides (HMOs) belong to a group of multifunctional glycans that are abundantly present in human breast milk. While health effects of neutral oligosaccharides have been investigated extensively, a lot remains unknown regarding health effects of acidic oligosaccharides, such as the two sialyllactoses (SLs), 3'sialyllactose (3'SL), and 6'sialyllactose (6'SL). We utilized () to investigate the effects of SLs on exercise performance.
View Article and Find Full Text PDFA Perspective on High-Intensity Interval Training for Performance and Health.
Sports Med
December 2023
Department of Kinesiology, McMaster University, 1280 Main St West, Hamilton, ON, L8S 4K1, Canada.
Interval training is a simple concept that refers to repeated bouts of relatively hard work interspersed with recovery periods of easier work or rest. The method has been used by high-level athletes for over a century to improve performance in endurance-type sports and events such as middle- and long-distance running. The concept of interval training to improve health, including in a rehabilitative context or when practiced by individuals who are relatively inactive or deconditioned, has also been advanced for decades.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!