AI Article Synopsis
- The study evaluated how different doses of the pneumococcal conjugate vaccine (PCV7) followed by a booster with the pneumococcal polysaccharide vaccine (PPV) affected immune response and bacteria carriage in infants.
- Infants received either one, two, or three doses of PCV7, and those with more doses showed significantly higher antibody levels against the vaccine strains (44% for one dose, 77% for two, and 94% for three).
- After the PPV booster, the differences in immune responses between the groups lessened, suggesting that using fewer doses of PCV7 followed by PPV can effectively protect young children against invasive pneumococcal disease in low-resource settings.
Article Abstract
The immunogenicity and impact on carriage of fewer doses of pneumococcal conjugate vaccine (PCV7) followed by booster with pneumococcal polysaccharide vaccine (PPV) were investigated. 684 infants were assigned randomly to one of the three groups that received one (A), two (B) or three (C) doses of PCV7 between 2 and 4 months of age, plus PPV at 10 months. Following primary vaccination protective antibody titers of >0.35 μg/ml against the PCV7 serotypes combined increased significantly with the number of PCV7 doses, 44% vs. 77% vs. 94% (p<0.001), and correlated positively with the opsonophagocytic indices, but negatively with nasopharyngeal carriage of pneumococcus. The differences in antibody responses and pneumococcal carriage between the groups diminished following booster with PPV, implying that administration of one or two doses of PCV7, with a booster dose of PPV might lower the cost of protection against IPD in young children in resource poor countries.
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| http://dx.doi.org/10.1016/j.vaccine.2011.01.098 | DOI Listing |
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