LMO4 is a novel member of the LIM-only (LMO) subfamily of LIM domain-containing transcription factors, so named because they are composed almost entirely of two tandem LIM domains. This subgroup of LIM proteins has 4 members: LMO-1, LMO-2, LMO-3 and LMO-4. They all play important roles in the normal mammalian development, functioning as an important regulator of cell proliferation. LMO4 is highly expressed in the epithelial compartments at locations of active epithelial-mesenchymal interactions, and can interact with some signaling pathways involved in epithelial-mesenchymal signaling. Thus the disregulation of LMO4 expression may be involved in tumorigenesis. In this paper, we will at first expound LMO4 in detail, based on which the possible mechanisms for its interaction with TGF-β signaling and the roles of this cross-talk between them in the vital process of cell will be introduced. All of those will add to our understanding of tumorigenesis and contribute to the search of new targets for the treatment of cancer.
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Genome-wide re-sequencing reveals regulatory genes and variants involved in the regulation of intermittent fertilization intensity in Wenchang chickens.
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Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, China.
Article Synopsis
- Intermittent fertilization intensity (IFI) in chickens affects fertilization rates, but its genetic basis remains unclear; this study investigates that relationship using 939 Wenchang chickens.
- Through genome-wide association studies, researchers identified 35 significant SNP variants linked to IFI on chromosome 8, particularly in the intron of a gene homogenous with human LMO4, suggesting a shared regulatory mechanism.
- The study highlights the role of immune regulation in the oviduct, with LMO4's activation related to inflammation, indicating that modifying LOC101750715 and LMO4 could lead to better fertilization outcomes in chickens.
Four-week inhibition of the renin-angiotensin system in spontaneously hypertensive rats results in persistently lower blood pressure with reduced kidney renin and changes in expression of relevant gene networks.
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Department of Anatomy & Physiology, School of Biomedical Sciences, University of Melbourne, Parkville, Victoria 3010, Australia.
Aims: Prevention of human hypertension is an important challenge and has been achieved in experimental models. Brief treatment with renin-angiotensin system (RAS) inhibitors permanently reduces the genetic hypertension of the spontaneously hypertensive rat (SHR). The kidney is involved in this fascinating phenomenon, but relevant changes in gene expression are unknown.
View Article and Find Full Text PDFPro-inflammatory cytokine IL-6 regulates LMO4 expression in psoriatic keratinocytes via AKT/STAT3 pathway.
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Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
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View Article and Find Full Text PDF4D-DIA quantitative proteomics revealed the core mechanism of diabetic retinopathy after berberine treatment.
Eur J Pharmacol
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Institute of Neuroscience, Kunming Medical University, Kunming, 650500, China; Department of Anatomy, College of Basic Medicine, Jinzhou Medical University, Jinzhou, 121000, China; Animal Center, Kunming Medical University, Kunming, 650500, China.
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Development of subdomains in the medial pallium of and : Insights into the anamniote-amniote transition.
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Department of Cell Biology, Faculty of Biology, Complutense University of Madrid, Madrid, Spain.
In all vertebrates, the most dorsal region of the telencephalon gives rise to the pallium, which in turn, is formed by at least four evolutionarily conserved histogenetic domains. Particularly in mammals, the medial pallium generates the hippocampal formation. Although this region is structurally different among amniotes, its functions, attributed to spatial memory and social behavior, as well as the specification of the histogenetic domain, appears to be conserved.
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