AI Article Synopsis
- Liposomes are effective for delivering drugs through the skin due to their ability to modify how drugs are distributed in the body.
- A study used lysine derivatives (Lys-5 and Lys-7) to enhance the structure of liposomes containing fluconazole and analyzed their impact on drug permeability.
- Results showed that these oligopeptides caused a structural change in the liposomes, reducing their size by 10% to 40% and slowing down the skin absorption of fluconazole.
Article Abstract
Liposomes are ideal dermal drug delivery systems because of their ability to alter the biodistribution profile of incorporated drugs. In a novel approach to optimize the liposomal microstructure, lysine derivatives were employed. The effect of the oligopeptides Lys-5 and Lys-7 on the structure as well as on the skin permeation of the antimycotic drug fluconazole in 1,2-dipalmitoyl-sn-glycero-3-phosphocholine vesicles was studied using a variety of techniques. It was demonstrated by addition of the shift reagent praseodymium(III)chloride and subsequent (31)P NMR measurements that the liposomes produced consisted mainly of unilamellar vesicles. This was confirmed by cryo-transmission electron microscopy. The addition of Lys-5 and Lys-7 induced a structural change resulting in a decrease in particle size between 10% and 40% and a retarding effect on fluconazole skin permeation.
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| http://dx.doi.org/10.1002/jps.22513 | DOI Listing |
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