Chemical construction of immunotoxins.

Methods Mol Med

Department of Microbiology and Cancer Immunobiology Center, The University of Texas South Western Medical Center at Dallas, TX.

Published: October 2012

Immunotoxins (ITs) are chimeric proteins consisting of an antibody linked to a toxin. The antibody confers specificity (ability to recognize and react with the target), whereas the toxin confers cytotoxicity (ability to kill the target) (1-3). ITs have been used in both mice and humans to eliminate tumor cells, autoimmune cells, and virus-infected cells (4-6.

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Source
http://dx.doi.org/10.1385/1-59259-075-6:1DOI Listing

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