Rule finding is an important aspect of human reasoning and flexibility. Previous studies associated rule finding failure with past experience with the test stimuli and stable personality traits. We additionally show that rule finding performance is severely impaired by a mindset associated with applying an instructed rule. The mindset was established in Phase 1 (manipulation) of the experiment, before rule finding ability was assessed in Phase 2 (testing). The impairment in rule finding was observed even when Phase 1 involved executing a single trial (Experiment 2), and when entirely different stimuli and rules were used in the two phases of the experiment (Experiments 3-6). Experiments 4-6 show that applying an instructed rule in Phase 1 impaired subsequent (Phase 2) feedback evaluation, rule generation, and attention switching between rules, which are the three component processes involved in rule finding according to COVIS (Ashby, Alfonso-Reese, Turken, & Waldron, 1998).
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http://dx.doi.org/10.1016/j.cognition.2011.01.002 | DOI Listing |
In Silico Pharmacol
January 2025
Teady Bioscience Research Laboratory, Ilara Mokin, Ondo State Nigeria.
Unlabelled: Breast cancer remains a global health challenge, with rising cases predicted in the coming decades. The complexity of breast cancer treatment arises from its complex nature, often involving multiple therapeutic strategies. One promising approach is targeting the ERK5 pathway, a key regulator in cancer cell proliferation and survival.
View Article and Find Full Text PDFActa Neuropathol Commun
January 2025
Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milan, Italy.
Deposition of abnormally phosphorylated tau aggregates is a central event leading to neuronal dysfunction and death in Alzheimer's disease (AD) and other tauopathies. Among tau aggregates, oligomers (TauOs) are considered the most toxic. AD brains show significant increase in TauOs compared to healthy controls, their concentration correlating with the severity of cognitive deficits and disease progression.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
January 2025
Hochschule für Gesundheitsfachberufe in Eberswalde, Schicklerstraße 20, 16225, Eberswalde, Germany.
The benefits and risks of delivery should always be considered before initiating preinduction cervical ripening and labor induction. Understanding the benefits and potential complications is crucial for healthcare professionals to make informed decisions and provide optimal care. The research was conducted retrospectively between January 2019 and July 2022.
View Article and Find Full Text PDFHamostaseologie
January 2025
Center for Clinical Transfusion Medicine Tuebingen, Tuebingen, Germany.
In this article, our goal is to offer an introduction and overview of the diagnostic approach to inherited platelet function defects (iPFDs) for clinicians and laboratory personnel who are beginning to engage in the field. We describe the most commonly used laboratory methods and propose a diagnostic four-step approach, wherein each stage requires a higher level of expertise and more specialized methods. It should be noted that our proposed approach differs from the ISTH Guidance on this topic in some points.
View Article and Find Full Text PDFLiver Int
February 2025
Division of Bioinformatics and Statistics, The FDA's National Center for Toxicological Research, Jefferson, Arkansas, USA.
Background And Aims: Acute liver failure (ALF) is a serious condition, typically in individuals without prior liver disease. Drug-induced ALF (DIALF) constitutes a major portion of ALF cases. Our research aimed to identify potential genetic predispositions to DIALF.
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