Vinorelbine is a semi-synthetic vinca-alkaloid with a broad spectrum anti-tumor activity. The dose-limiting toxicity of vinorelbine is neutropenia and leucopenia which is seen in majority of the patients. The previous case reports on the cardiac toxicity occurred mainly in combination therapy of vinorelbine with cisplatin or carboplatin. We offer evidence that acute coronary syndrome and resultant diastolic heart failure developed as a result of acute bronchospasm due to intravenous vinorelbine monotherapy.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Prevalence and Economic Impact of Acute Respiratory Failure in the Prehospital Emergency Medical Service of the Madrid Community: Retrospective Cohort Study.
JMIR Public Health Surveill
January 2025
Department of Medicine, Division of Family Medicine and Primary Care, Clinical Simulation Laboratory, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
Background: Chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), and acute pulmonary edema (APE) are serious illnesses that often require acute care from prehospital emergency medical services (EMSs). These respiratory diseases that cause acute respiratory failure (ARF) are one of the main reasons for hospitalization and death, generating high health care costs. The prevalence of the main respiratory diseases treated in a prehospital environment in the prepandemic period and during the COVID-19 pandemic in Spain is unknown.
View Article and Find Full Text PDFBronchoscopic lung lavage and exogenous surfactant successfully reverse respiratory failure after severe chlorine exposure: A pediatric case report.
Clin Case Rep
January 2025
Pediatric Intensive Care Unit, Department of Maternal and Child Health and Urological Sciences Sapienza University of Rome Rome Italy.
Key Clinical Message: Although the symptoms of accidental chlorine inhalation are typically mild, severe exposure can result in acute respiratory distress syndrome (ARDS). We present a case of pediatric ARDS due to chlorine exposure in which lung lavage and exogenous surfactant were successful in avoiding more invasive and costly treatments.
Abstract: Chlorine inhalation as a result of swimming pool chlorination accidents is relatively common.
The assessment of exhaled nitric oxide in patients with obesity and asthma before and after exercise.
J Asthma
January 2025
Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Objective: It is well-known that children who suffer from obesity and asthma may also have exercise-induced bronchospasm. Exhaled nitric oxide is an indicator of airway inflammation, and could be affected by exercise. This study looked at how exercise, which is a typical cause of acute airway obstruction, affects the levels of FeNO and spirometric parameters in obese and asthmatic children.
View Article and Find Full Text PDFOccupational anaphylaxis: A Position Paper of the German Society of Allergology and Clinical Immunology (DGAKI).
Allergol Select
November 2024
Department of Dermatology and Allergy Biederstein, School of Medicine and Health, Technical University of Munich TUM).
Background: Anaphylaxis is a systemic allergic reaction that is potentially life-threatening. Occupational anaphylaxis is an anaphylaxis that occurs in an occupational context. In this position paper, we propose diagnostic criteria for occupational anaphylaxis and provide an overview of the current state of knowledge in terms of prevalence, triggers, prevention, and management.
View Article and Find Full Text PDFManagement and Follow-Up of a Cohort of Neonates With Meconium Aspiration Syndrome Before and After the Revision of the 2015 Neonatal Resuscitation Program.
Cureus
November 2024
Neonatology Department, Unidade Local de Saúde (ULS) de Coimbra, Coimbra, PRT.
Article Synopsis
- - Meconium aspiration syndrome (MAS) is a serious respiratory issue in newborns that can lead to long-term health problems, prompting updates in care standards, particularly the 2015 Neonatal Resuscitation Program (NRP) to improve outcomes.
- - A 15-year study analyzed outcomes for MAS patients before and after the revised NRP, finding increased use of positive pressure ventilation in delivery rooms, but no significant changes in overall morbidity or clinical outcomes, except for improved acidosis and reduced hyperlactatemia.
- - While the updated NRP did not negatively affect clinical outcomes, challenges like cerebral palsy and global development delays remain prevalent, highlighting the ongoing impact of MAS on health even after interventions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!