AI Article Synopsis
- The study investigated the impact of the fungicide PF-70, containing sulphur, mancozeb, and triadimefon, on the gastric mucosa electrolyte barrier in Wistar rats over 13 weeks.
- Evidence of mucosal lesions, a risk factor for chronic peptic ulcer disease, was assessed by measuring transmural electric potential differences before and after exposure to hydrochloric acid and acetylsalicylic acid.
- Results indicated no overall health changes in the rats, but males showed increased food intake at higher doses, while females experienced body mass loss at the highest dose, with all groups showing decreased electric potential differences, signaling damage to the mucosa.
Article Abstract
The fungicide for corn PF-70 contains 21% of sulphur, 8.4% of mancozeb, and 0.6% of triadimefon . The aim of the study was to determine the effect of the fungicide on the gastric mucosa electrolyte barrier in rats. Mucosa lesion is known to be one of the risk factors of chronic peptic ulcer disease. The experiments were carried out on 80 rats of Wistar strain. The animals were divided into 5 groups--males and females, separately. The fungicide was given for 13 weeks, at the following doses: 100, 400, 1600, and 6400 mg of active substance per 1 kg of fodder. The gastric mucosa electrolyte barrier was examined by determining the transmural electric potential differences (PD) in mucosa before and after treatment with 150 mmlo of hydrochloric acid and 40 mmol of acetylsalicylic acid solutions. No changes in general condition of the animals were observed. An increase in fodder consumption was observed in males receiving the fungicide at doses of 1600 and 6400 mg per 1 kg of fodder. Females exhibited a decrease in body mass after intoxication at concentration of 6400 mg/kg fodder. A decrease in PD was found in all groups intoxicated with the fungicide, irrespective of the animal sex.
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