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A model-based risk-minimizing proton treatment planning concept for brain injury prevention in low-grade glioma patients.
Radiother Oncol
December 2024
Department of Radiation Oncology and Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany; National Center for Tumor Diseases (NCT), Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Purpose: Late-occurring contrast-enhancing brain lesions (CEBLs) have been observed on MRI follow-up in low-grade glioma (LGG) patients post-proton therapy. Predictive risk-models for this endpoint identified a dose-averaged linear energy transfer (LET)-dependent proton relative biological effectiveness (RBE) effect on CEBL occurrence and increased radiosensitivity of the cerebral periventricular region (VP). This work aimed to design a stable risk-minimizing treatment planning (TP) concept addressing these intertwined risk factors through a classically formulated optimization problem.
View Article and Find Full Text PDFA near normal distribution of IQ in Fragile X Syndrome.
Sci Rep
October 2024
Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229- 3039, USA.
Fragile X Syndrome (FXS) is an X-linked disorder leading to the loss of expression of FMR1-protein product, FMRP. The absence or deficiency of FMRP is thought to result in the characteristic FXS phenotypes, including intellectual disability. Identifying the relationship between FMRP levels and IQ may be critical to better understand underlying mechanisms and advance treatment development and planning.
View Article and Find Full Text PDFThe next stages of treatment-oriented research: Commentary on Wade et al. (2023).
Int J Eat Disord
June 2024
New York State Psychiatric Institute and Columbia University Irving Medical Center, New York, New York, USA.
Treatments for eating disorders have established benefits; yet, current psychotherapies focus specifically on the cognitions and behaviors of the eating disorder. Wade et al. (2023) propose that the myriad symptoms and disorders that occur together with eating disorders merit specific attention in treatment research protocols.
View Article and Find Full Text PDFFragile X Syndrome (FXS) is an X-linked disorder leading to the loss of expression of -protein product, FMRP. The absence or deficiency of FMRP is thought to result in the characteristic FXS phenotypes, including intellectual disability. Identifying the relationship between FMRP levels and IQ may be critical to better understand underlying mechanisms and advance treatment development and planning.
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