Objective: We pilot tested the efficacy of computer-based training implementing rhythm and timing in chronic, severe, stroke-induced hemiparesis.
Method: Two chronic stroke patients were administered the upper-extremity section of the Fugl-Meyer Impairment Scale (FM), the Arm Motor Ability Test (AMAT), Stroke Impact Scale (SIS), and Canadian Occupational Performance Measure (COPM). We then administered the computer-based intervention for 60 min, 3 days/wk for 4 wk. One week after intervention, we administered the FM, AMAT, COPM, and SIS.
Results: After intervention, participants exhibited reduced arm impairment (indicated by FM scores of + 2.0 and +4.0) and increases in average functional ability (+0.85 and +1.1 points on the AMAT), perceived quality of life (+2.0 and +32.0 points on the SIS), and perception of overall recovery (+10.0 points for each participant on the SIS).
Conclusion: This study provides preliminary evidence suggesting efficacy of computer-based rhythm and timing in chronic stroke.
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http://dx.doi.org/10.5014/ajot.2011.09158 | DOI Listing |
Front Neurosci
January 2025
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
The circadian clock regulates physiological and biochemical processes in nearly every species. Sexual and reproductive behaviors are two processes controlled by the circadian timing system. Evidence supporting the importance of proper clock function on fertility comes from several lines of work demonstrating that misalignment of biological rhythms or disrupted function of the body's master clock, such as occurs from repeated shift work or chronic jet lag, negatively impacts reproduction by interfering with both male and female fertility.
View Article and Find Full Text PDFMol Plant
January 2025
Division of Applied Life Sciences (BK21(+)), Plant Biological Rhythm Research Center and PMBBRC, Gyeongsang National University, Jinju-52828, Korea. Electronic address:
The intricate interplay between cellular circadian rhythms, primarily manifested in the chloroplast redox oscillations-characterized by diel hyperoxidation/reduction cycles of 2-Cys Peroxiredoxins-and the nuclear transcription/translation feedback loop (TTFL) machinery within plant cells, demonstrates a remarkable temporal coherence. However, the molecular mechanisms underlying the integration of these circadian rhythms remain elusive. Here, we elucidate that the chloroplast redox protein, NADPH-dependent thioredoxin reductase type-C (NTRC), modulates the integration of the chloroplast redox rhythms and nuclear circadian clocks by regulating intracellular levels of reactive oxygen species and sucrose.
View Article and Find Full Text PDFBiofactors
January 2025
Departament de Bioquimica i Biotecnologia, Universitat Rovira i Virgili, Nutrigenomics Research Group, Tarragona, Spain.
Current lifestyles include calorie-dense diets and late-night food intake, which can lead to circadian misalignment. Our group recently demonstrated that sweet treats before bedtime alter the clock system in healthy rats, increasing metabolic risk factors. Therefore, we aimed to assess the impact of the sweet treat consumption time on the clock system in rats fed a cafeteria diet (CAF).
View Article and Find Full Text PDFMol Metab
January 2025
Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia, Spain; Institute of Biomedical Research of Murcia, Virgen de la Arrixaca University Hospital, Murcia, Spain. Electronic address:
Circadian rhythms of metabolic, hormonal, and behavioral fluctuations and their alterations can impact health. An important gap in knowledge in the field is whether the time of the day of exercise and the age of onset of exercise exert distinct effects at the level of whole-body adipose tissue and body composition. The goal of the present study was to determine how exercise at different times of the day during adolescence impacts the adipose tissue transcriptome and content in a rodent model.
View Article and Find Full Text PDFEur J Neurosci
January 2025
Institute of Physiology, Sleep Research & Clinical Chronobiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Timing and architecture of sleep are co-driven by circadian rhythms modulated by their major Zeitgeber light and darkness. In a natural environment, one is exposed to 3.000 lx (cloudy winter sky) to 100.
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