AI Article Synopsis
- Brain parenchymal involvement in mantle cell lymphoma is rare and is associated with a poor prognosis.
- Most patients show leptomeningeal involvement with malignant cells in the cerebrospinal fluid, rather than direct brain tissue involvement.
- The case study presented is unique, featuring a biopsy-confirmed mass lesion in the brain as a sign of relapse just 6 months post-diagnosis.
Article Abstract
Brain parenchymal involvement by mantle cell lymphoma is rare and confers a grim prognosis. More commonly, patients with central nervous system manifestations of mantle cell lymphoma have leptomeningeal involvement on radiographic studies with malignant cells found in the cerebrospinal fluid. Risk factors for central nervous system involvement include a high proliferation index, bone marrow involvement, and blastoid morphology. We present an unusual case of a biopsy-proven mantle cell lymphoma mass lesion in the brain parenchyma as the presentation of relapse 6 months after diagnosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012289 | PMC |
| http://dx.doi.org/10.1080/08998280.2011.11928681 | DOI Listing |
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