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Factors Associated With the Recovery of Left Ventricular Ejection Fraction in Patients With Anthracycline-Induced Left Ventricular Dysfunction.
J Cardiovasc Pharmacol Ther
January 2025
Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Background: Neurohormonal blocking drugs, like beta-blockers, angiotensin-converting enzyme inhibitors (ACEIs), and angiotensin receptor blockers (ARBs), are recommended for treating anthracycline-induced left ventricular dysfunction (AILVD). However, there is limited evidence supporting their benefit. Therefore, this study evaluated associations of neurohormonal blockers and other clinical factors with recovery of left ventricular ejection fraction (LVEF) in patients with AILVD.
View Article and Find Full Text PDFMetagenomics unveils the role of hospitals and wastewater treatment plants on the environmental burden of antibiotic resistance genes and opportunistic pathogens.
Sci Total Environ
January 2025
School of Environmental and Natural Sciences, Bangor University, Bangor, Gwynedd Ll57 2UW, UK.
Antimicrobial resistance (AMR) is a global health challenge, with hospitals and wastewater treatment plants (WWTPs) serving as significant pathways for the dissemination of antibiotic resistance genes (ARGs). This study investigates the potential of wastewater-based epidemiology (WBE) as an early warning system for assessing the burden of AMR at the population level. In this comprehensive year-long study, effluent was collected weekly from three large hospitals, and treated and untreated wastewater were collected monthly from three associated community WWTPs.
View Article and Find Full Text PDFMacrogenomic Analysis Reveals Soil Microbial Diversity in Different Regions of the Antarctic Peninsula.
Microorganisms
November 2024
College of Life Science, Yantai University, Yantai 264005, China.
Article Synopsis
- The Antarctic Peninsula has unique ecosystems, heavily relying on microorganisms for ecological balance, but there's limited knowledge about soil microbial community diversity across the region.
- Metagenome sequencing was employed to assess soil microbes in four specific locations, revealing insights into their composition and functions.
- Results indicated variations in bacterial types and their functions across locations, including the presence of numerous antibiotic resistance genes linked to human activities, highlighting the need for careful management of Antarctic microbial resources.
Progress in antileishmanial drugs: Mechanisms, challenges, and prospects.
PLoS Negl Trop Dis
January 2025
Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, continues to pose global health challenges. Current treatments face issues like resistance, safety, efficacy, and cost. This review covers the discovery, mechanisms of action, clinical applications, and limitations of key antileishmanial agents: pentavalent antimonials, amphotericin B, miltefosine, paromomycin, and pentamidine.
View Article and Find Full Text PDFAdvancements in MRSA treatment: the role of berberine in enhancing antibiotic therapy.
BMC Microbiol
December 2024
Department of Clinical Laboratory, Shanghai Eighth People's Hospital, No.8 Caobao Road, Xuhui District, Shanghai, 200235, P.R. China.
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant public health problem. This study investigated the antimicrobial properties and mechanisms of berberine (BBR), a plant alkaloid, against MRSA, evaluating its potential to enhance antibiotic therapy.
Results: Berberine only demonstrated variable but significant inhibitory effects on 50 clinical MRSA strains.
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