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Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma.
BMC Med
December 2024
Biology Department, Boston College, Chestnut Hill, MA, 02467, USA.
Article Synopsis
- Glioblastoma (GBM) is the deadliest brain tumor in adults, and current therapies are largely ineffective, which drives the need for new treatment strategies based on the tumor's metabolic needs, specifically glucose and glutamine.
- A ketogenic metabolic therapy (KMT) approach targets these metabolic pathways by combining dietary changes with specific drugs to limit glycolysis and glutaminolysis, while promoting the use of non-fermentable fuels like ketones and fatty acids.
- The glucose-ketone index (GKI) serves as a biomarker to monitor treatment effectiveness, aiming to create a more hostile environment for tumor growth and improve outcomes in GBM as well as potentially other cancer types reliant on similar metabolic pathways.
Tactile mechanisms and afferents underlying the rat pup transport response.
Curr Biol
December 2024
Neural Systems & Behavior, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA; University of Edinburgh, Simons Initiative for the Developing Brain, 1 George Square, EH8 9JZ Edinburgh, Scotland, United Kingdom. Electronic address:
Juvenile rodents and other altricial mammals react with calming, immobility, and postural modifications to parental pickup, a set of behaviors referred to as the transport response. Here, we investigate sensory mechanisms underlying the rat transport response. Grasping rat pups in anterior neck positions evokes strong immobility and folding up of feet, whereas more posterior grasping has lesser effects on immobility and foot position.
View Article and Find Full Text PDFSensory cues, behavior and fur-based drying in the rat wetness response.
Sci Rep
October 2024
Neural Systems & Behavior, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA, 02543, USA.
Article Synopsis
- - The study explores how rats react to getting wet, since standard lab settings don’t typically provide insights into animal behavior in wet conditions.
- - When water was sprayed on rats, they exhibited specific behaviors like grooming and shaking, and the drying process varied based on where the water was applied on their bodies.
- - The research suggests that fur helps with evaporation and the cooling process during drying, leading to the development of the "wet-fur-heat-pump-hypothesis," which proposes that fur cools down air to aid in drying.
Simultaneous laser ultrasonic measurement of sound velocities and thickness of plates using combined mode local acoustic spectroscopy.
Ultrasonics
January 2025
Research Center for Non-Destructive Testing GmbH (RECENDT), Altenberger Straße 69, 4040 Linz, Austria. Electronic address:
Standard ultrasonic thickness measurements require the sound velocity of the sample to be known and vice versa. We present a method, which we have termed combined mode local acoustic spectroscopy (CoMLAS) for simultaneously determining a plate's thickness and sound velocities without requiring such a priori knowledge. It is based on a combination of three guided wave modes sustained by a plate at discrete frequencies, which we generate and detect using laser ultrasound.
View Article and Find Full Text PDFTactile Mechanisms and Afferents Underlying the Rat Pup Transport Response.
bioRxiv
August 2024
Neural Systems & Behavior, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543 USA.
Juvenile rodents and other altricial mammals react with calming, immobility and folding up of feet to parental pickup, a set of behaviors referred to as transport response. Here we investigate sensory mechanisms underlying the rat transport response. Grasping rat pups in anterior neck positions evokes strong immobility and folding up of feet, whereas more posterior grasping positions have lesser effects on immobility and foot position.
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