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Poly(ε-lysine) (ε-PL)-analogous click polypeptides with not only similar α-amino side groups but also similar main chain to ε-PL were chemically synthesized for the first time through click polymerization from aspartic (or glutamic)-acid-based dialkyne and diazide monomers. With microwave-assisting, the reaction time of click polymerization was compressed into 30 min. The polymers were fully characterized by NMR, ATR-FTIR, and SEC-MALLS analysis. The deprotected click polypeptides had similar pK(a) value (7.5) and relatively low cytotoxicity as ε-PL and could be used as substitutes of ε-PL in biomedical applications, especially in endotoxin selective removal. Poly(ethylene glycol) (PEG)-containing alternating copolymers with α-amino groups were also synthesized and characterized. After deprotection, the polymers could be used as functional gene vector with PEG shadowing system and NCA initiator to get amphiphilic graft polymers.
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http://dx.doi.org/10.1021/bm1013662 | DOI Listing |
Int J Biol Macromol
December 2024
Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand; Research and Innovation Center for Advanced Therapy Medicinal Products, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand. Electronic address:
This study aimed to develop cisplatin (CDDP)-loaded folic acid (FA)-decorated nanoparticles (NPs) as targeted drug carrier towards overexpressed folate receptors on the oral carcinoma cell line (KB cells). The FA-conjugated thiolated succinyl chitosan (FA-SH-SCS) and maleimide-grafted-carboxymethyl cellulose (CMC-MAL) were synthesized and acquired in the preparation of NPs via thiol-maleimide click reaction. The physicochemical characteristics, drug loading, and drug release of the FA-decorated NPs (FA-NPs) were examined.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Technical University of MunichTUM School of Natural Sciences, Department of Chemistry, WACKER-Chair of Macromolecular Chemistry, Lichtenbergstraße 485748 Garching, Germany.
Herein, novel, superabsorbent, and pH-responsive hydrogels obtained by the photochemical cross-linking of hydrophilic poly(vinylphosphonates) are introduced. First, statistical copolymers of diethyl vinylphosphonate (DEVP) and diallyl vinylphosphonate (DAlVP) are synthesized via rare earth metal-mediated group-transfer polymerization (REM-GTP) yielding similar molecular weights ( = 127-142 kg/mol) and narrow polydispersities ( < 1.12).
View Article and Find Full Text PDFAnal Chem
December 2024
Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Highly sensitive and accurate detection of disease biomarkers is of great importance for diagnosis, staging, and treatment of certain diseases. Herein, we report a novel electrochemical method for the quantification of miRNA biomarkers with DNA tetrahedrons as the signal reporters. Upon the initiation of DNA hairpin opening by miRNA at the electrode interface, the hidden click reaction group is exposed for the bioconjugation with a tetrahedral DNA nanostructure, which carries multiple electrochemical species.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
University of Western Ontario: Western University, Chemistry, CANADA.
The development of polymers from renewable resources is a promising approach to reduce reliance on petrochemicals. In addition, depolymerization is attracting significant attention for the breakdown of polymers at their end-of-life or to achieve specific stimuli-responsive functions. However, the design of polymers incorporating both of these features remains a challenge.
View Article and Find Full Text PDFPolymers (Basel)
November 2024
Department of Applied Chemistry, Chemical Engineering, and Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa 992-8510, Yamagata, Japan.
Graft copolymers have gained significant importance in various fields due to their tunable functionality and well-defined architecture. However, there are still limitations due to the compatibility of monomers and functional groups depending on the polymerization mode. Click chemistry has solved this problem through its ability to easily and quantitatively link a wide range of polymers and functional groups.
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