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Successful Clozapine Treatment for Treatment-Resistant Schizophrenia With Zinc Deficiency Severe Anemia: A Case Report.
Neuropsychopharmacol Rep
March 2025
Department of Neuropsychiatry, School of Medicine, Wakayama Medical University, Wakayama, Wakayama, Japan.
Introduction: Clozapine is an atypical antipsychotic drug approved for treatment-resistant schizophrenia (TRS). Despite its high efficacy for TRS, clozapine is associated with several serious adverse effects, such as neutropenia and diabetes, so it requires vigilant monitoring. Severe anemia has also been documented as a rare but serious complication with an unclear mechanism.
View Article and Find Full Text PDFClozapine and rapamycin reverse behavioral abnormalities in an animal model of autoimmune schizophrenia.
Neuropharmacology
March 2025
State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:
Objective: Autoantibody-associated psychosis represents a distinct disease subgroup of patients with schizophrenia with a suspected autoimmune origin. Although preliminary studies have suggested adjunctive drug treatment strategies targeting the immune system, further validation of these findings is warranted. Autoantibodies against SFT2D2 have been identified in patients with schizophrenia.
View Article and Find Full Text PDFMultimodal prediction of the need of clozapine in treatment resistant schizophrenia; a pilot study in first-episode psychosis.
Biomark Neuropsychiatry
December 2024
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
As many as one third of the patients diagnosed with schizophrenia do not respond to first-line antipsychotic medication. This group may benefit from the atypical antipsychotic medication clozapine, but initiation of treatment is often delayed, which may worsen prognosis. Predicting which patients do not respond to traditional antipsychotic medication at the onset of symptoms would provide fast-tracked treatment for this group of patients.
View Article and Find Full Text PDFClozapine is a functional antagonist at cardiac human H-histamine receptors.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Institute for Pharmacology and Toxicology, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Magdeburger Straße 4, Halle (Saale), D-06097, Germany.
Clozapine is an atypical antipsychotic (neuroleptic) drug. Clozapine binds to H-histamine receptors in vitro. We wanted to test the hypothesis that clozapine might be a functional antagonist at human cardiac H-histamine receptors.
View Article and Find Full Text PDFGenetic identification of undiagnosed benign ethnic neutropenia in patients receiving clozapine treatment.
Br J Psychiatry
December 2024
Institute of Pharmaceutical Sciences, King's College London, UK; and Pharmacy Department, South London and Maudsley NHS Foundation Trust, London, UK.
Article Synopsis
- Clozapine therapy can lead to agranulocytosis, which requires monitoring of white blood cell counts, and it's crucial to identify benign ethnic neutropenia (BEN) to avoid unnecessary clozapine withdrawal.
- * A study introduced voluntary genetic testing for BEN in a clozapine clinic to determine how many patients had undiagnosed BEN, finding that 24% of participants were newly diagnosed with this condition.
- * Results showed that undiagnosed BEN was common among patients, suggesting that adding genetic testing to regular monitoring could improve clozapine therapy management and enable safe continuation for those with unrecognized BEN.
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