Because omental flaps are useful for flap prefabrication and the cambium layer of the periosteum can be osteogenic, we examined whether calvarial periosteum grafted onto greater omentum of rats was osteogenic and suitable for a flap. Distal omentum was wrapped with calvarial periosteum and so the cambium faced the omentum. Grafted omentum was harvested at 1 to 9 days. In other rats, grafted omentum was elevated as a pedicled flap and moved to the abdominal subcutis, to be harvested later at 1 to 5 months after the initial surgery. Bone formation was evaluated histologically, histochemically, and radiographically. On day 3, osteoid had formed. From day 4, calvarial periosteum was revascularized by omentum and bone was forming. New bone was maintained after grafting to subcutis for 5 months. Thus, bone formed by periosteum on the omentum could be used to reconstruct defects of the bone.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/SAP.0b013e31820456fe | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of preparation technique on periosteal microcirculation after autologous bone augmentation in an animal model.
J Oral Implantol
December 2024
Hannover Medical School Department of Oral and Maxillofacial Surgery Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Trial Design: This controlled in vivo experimental study examines the impact of two periosteum preparation techniques on microcirculation during bone augmentation with isogenic bone grafts in rats.
Methods: Twenty female Lewis rats were divided into two groups (n=10 each). In one group, the periosteum was prepared with a conventional periosteal elevator; in the other, a piezoelectric device was used.
A Bottom-Up Approach to Assemble Cell-Laden Biomineralized Nanofiber Mats into 3D Multilayer Periosteum Mimics for Bone Regeneration.
Nano Lett
November 2024
National Engineering Research Center for Biomaterials, Department of Biomedical Engineering, Sichuan University, Chengdu 610064, China.
The creation of complex multilayer periosteal graft structures is challenging. This study introduced a novel bottom-up approach to assemble cell-laden nanofiber mats into a three-dimensional (3D) multilayer periosteum mimic, successfully replicating the hierarchical complexity of the natural periosteum. These nanofiber mats, which were fabricated by electrospinning, surface modification, and stimulated body fluid (SBF) immersion, are composed of nanoscale polycaprolactone (PCL) fibers coated with a mineralized collagen layer along the fiber orientation.
View Article and Find Full Text PDFβ-Tricalcium phosphate incorporated natural rubber latex membranes for calvarial bone defects: Physicochemical, in vitro and in vivo assessment.
Int J Biol Macromol
December 2024
Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. Electronic address:
Natural rubber latex membrane (NRL) is a biocompatible macromolecule that stimulates angiogenesis and promotes bone repair. Similarly, β-tricalcium phosphate (β-TCP) is an osteoconductive and osteoinductive bioceramic widely used as a bone substitute. Here, we investigated the combined use of these biomaterials in the guided bone regeneration process for calvarial defects in rats.
View Article and Find Full Text PDFExosomes derived from mucoperiosteum Krt14Ctsk cells promote bone regeneration by coupling enhanced osteogenesis and angiogenesis.
Biomater Sci
November 2024
Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P.R. China.
Article Synopsis
- Repairing large bone defects involves complex processes where different cell types interact to regenerate bone, making it a complex but interesting area of study.
- Exosomes, tiny vesicles that help cells communicate, play a crucial role in this repair process and have emerged as a promising treatment option due to their effective properties and ability to minimize immune reactions.
- This study found that exosomes from a specific cell type (Krt14Ctsk) significantly boost the growth and migration of blood vessel cells, enhance bone formation markers, and improve healing in bone defects, indicating their potential for advancing bone repair therapies.
A bilayer hydrogel mimicking the periosteum-bone structure for innervated bone regeneration.
J Mater Chem B
November 2024
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.
In bone tissue, nerves are primarily located in the periosteum and play an indispensable role in bone defect repair. However, most bone tissue engineering approaches ignored the reconstruction of the nerve network. Herein, we aimed to develop a bilayer hydrogel simulating periosteum-bone structure to induce innervated bone regeneration.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!