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Re-thinking the possible interaction between proton pump inhibitors and capecitabine.
Cancer Chemother Pharmacol
November 2022
Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Proton Pump Inhibitors (PPI) rank within the top ten most prescribed medications in Europe and USA. A high frequency of PPI use has been reported amongst patients undergoing chemotherapy, to mitigate treatment-induced gastritis or gastro-oesophageal reflux. Several recent, mostly retrospective, observational studies have reported inferior survival outcomes among patients on capecitabine who concomitantly use PPI.
View Article and Find Full Text PDFRe-thinking benign inflammation of the lactating breast: Classification, prevention, and management.
Womens Health (Lond)
April 2022
School of Nursing and Midwifery, Griffith University, Brisbane, QLD, Australia.
Despite the known benefits of breastfeeding for both infant and mother, clinical support for problems such as benign inflammation of the lactating breast remain a research frontier. Breast pain associated with inflammation is a common reason for premature weaning. Multiple diagnoses are used for benign inflammatory conditions of the lactating breast which lack agreed or evidence-based aetiology, definitions, and treatment.
View Article and Find Full Text PDFLarge-Scale Mercury Dispersion at Sea: Modelling a Multi-Hazard Case Study from Augusta Bay (Central Mediterranean Sea).
Int J Environ Res Public Health
March 2022
Consiglio Nazionale delle Ricerche, Istituto di Scienze Marine, 80133 Napoli, Italy.
This contribution discusses an example of potential multi-hazard effects resulting from an earthquake in a highly seismogenic area of the Mediterranean Sea, the Augusta Bay, which presents high levels of contamination in sediments and seawater, due particularly to high-concentrations of mercury as a result of a long-term industrial exploitation. In particular, a high-resolution hydrodynamic and transport model is used to calculate the effects of enhanced mercury spreading in the open sea after significant damage and collapse of the artificial damming system confining the embayment where a very high concentration of Hg occurs in seafloor sediments and seawater. Coupling high-resolution 3D dynamic circulation modelling and sediment-seawater Hg fluxes calculated using the HR3DHG diffusion-reaction model for both inorganic and organic Hg species offers a valuable approach to simulating and estimating the effects of spatial dispersion of this contaminant due to unpredictable hazard events in coastal systems, with the potential attendant enhanced effects on the marine ecosystem.
View Article and Find Full Text PDFRe-thinking benign inflammation of the lactating breast: A mechanobiological model.
Womens Health (Lond)
February 2022
School of Nursing and Midwifery, Griffith University, Brisbane, QLD, Australia.
Despite the known benefits of breastfeeding for both infant and mother, clinical support for problems such as inflammation of the lactating breast remains a research frontier. Breast pain associated with inflammation is a common reason for premature weaning. Multiple diagnoses are used for inflammatory conditions of the lactating breast, such as engorgement, blocked ducts, phlegmon, mammary candidiasis, subacute mastitis, mastitis and white spots, which lack agreed or evidence-based aetiology, definitions and treatment.
View Article and Find Full Text PDFRe-thinking recovery in post-conflict settings: Supporting the mental well-being of communities in Colombia.
Glob Public Health
February 2020
Psychology Department, Universidad de La Sabana, Chia, Colombia.
Addressing mental health needs is a central focus of the Colombian Government's framework for socio-political reconstruction following over 60 years of conflict. Informed by WHO standards, country efforts utilise biopsychosocial models that prioritise individual psychological and psychiatric conditions. However, increasing scrutiny of the deployment of Western approaches to mental health and recovery in the global south suggests a need to explore the best route to improving mental health outcomes.
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