The creation of sialoliths in the ductal system of major salivary glands causes characteristic symptoms due to the obstruction of the flow of produced saliva. If sialolithiasis is not treated early obstructive sialadenitis will develop and its repeated relapses may lead to fibrosis and degeneration of glandular parenchyma. In this study we present the method of intraglandular injection of biotherapeutic solution (1.000.000 I.U. penicillin G in 5 cc normal saline) to achieve treatment of obstructive sialadenitis and rejection of the sialolith. Our results as shown in tables I and II and in figures 1-9 are very encouraging. From the conclusions drawn it looks like this method can be recommended as an optional solution to surgery (lithectomy-adenectomy) under the conditions mentioned in the discussion.

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