As a study method of resting state network (RSN), resting state functional MRI (rfMRI) can be applied to detect low frequency fluctuate (LFF) in various cerebral areas based on resting state blood oxygen level dependence (BOLD) signals; and it is easier and more consistent than task-related fMRI. The development, features and methods of rfMRI as well as the application in epilepsy were reviewed in this article.
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http://dx.doi.org/10.1016/j.braindev.2011.01.001 | DOI Listing |
Front Psychol
December 2024
Neuroscience Institute of Turin, University of Turin, Turin, Italy.
If "theory of mind" is conceived as reasoning in a strict sense, then it can be said to be useful only at certain times; however, this leaves the rest of social cognition hardly comprehensible. If "theory of mind" is used instead to refer to a mentalist ontology and the consequent awareness that we ourselves and the others function on mental states, then we need new approaches that explain the flow of social experience. To illustrate these points, we outline the general conceptual framework that underlies most empirical studies of theory of mind and discuss their pros and cons; then, we discuss the Theory of Mind Assessment Scale, a tool developed to investigate the complexity of theory of mind, which adopts a different perspective and has been successfully tested on numerous populations.
View Article and Find Full Text PDFCytochrome P450s (CYPs) are a superfamily of thiolate-ligated heme metalloenzymes principally responsible for the hydroxylation of unactivated C-H bonds. The lower-axial cysteine is an obligatory and universally conserved residue for the CYP enzyme class. Herein, we challenge this paradigm by systematically identifying non-canonical CYPs (ncCYPs) that do not harbor a cysteine ligand.
View Article and Find Full Text PDFBrain functional connectivity patterns exhibit distinctive, individualized characteristics capable of distinguishing one individual from others, like fingerprint. Accurate and reliable depiction of individualized functional connectivity patterns during infancy is crucial for advancing our understanding of individual uniqueness and variability of the intrinsic functional architecture during dynamic early brain development, as well as its role in neurodevelopmental disorders. However, the highly dynamic and rapidly developing nature of the infant brain presents significant challenges in capturing robust and stable functional fingerprint, resulting in low accuracy in individual identification over ages during infancy using functional connectivity.
View Article and Find Full Text PDFObjective: Bile acids may contribute to pathophysiologic markers of Alzheimer's disease, including disruptions of the executive control network (ECN) and the default mode network (DMN). Cognitive dysfunction is common in major depressive disorder (MDD), but whether bile acids impact these networks in MDD patients is unknown.
Methods: Resting state functional magnetic resonance imaging (fMRI) scans and blood measures of four bile acids from 74 treatment-naïve adults with MDD were analyzed.
The striatum is divided into two interdigitated tissue compartments, the striosome and matrix. These compartments exhibit distinct anatomical, neurochemical, and pharmacological characteristics and have separable roles in motor and mood functions. Little is known about the functions of these compartments in humans.
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